Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
PINK1
mRNA |
Kinase that initiates PRKN-dependent mitophagy on damaged mitochondria. | PINK1/PRKN mitophagy supports TNBC cell survival and chemoresistance; inhibiting this axis sensitizes cells to therapy. | Breast Cancer |
PubMed
Reference PMID: 33929971 |
|
STING1
mRNA |
cGAS�STING signaling supports TNBC growth; pathway inhibition triggers autophagy-dependent cell death, implicating autophagy in STING-driven survival. | Pro-survival pathway in TNBC; blocking STING induces autophagy-dependent death in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 35992877 |
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | Breast Cancer |
PubMed
Reference PMID: 35467897 |
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | Breast Cancer |
PubMed
Reference PMID: 28017659 |
|
HK2
mRNA |
HK2 is targeted by miR-216b, leading to inhibition of the mTOR pathway, which in turn stimulates autophagy | miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC | Breast Cancer |
PubMed
Reference PMID: 34345220 |
|
TOLLIP
mRNA |
Autophagy receptor mediating selective autophagic degradation of TMEM63A/DERL1 axis. | TOLLIP-mediated autophagic degradation pathway drives TNBC progression; disrupting VCP/TMEM63A/DERL1 reduces oncogenic effects in vitro and in vivo. | Breast Cancer |
PubMed
Reference PMID: 35920704 |
|
NOD2
mRNA |
NOD2 drives innate immune signaling and autophagy in cancer | Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role. | Breast Cancer |
PubMed
Reference PMID: 29615116 |
|
NOD2
mRNA |
NOD2 drives innate immune signaling and autophagy in cancer | Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role. | Breast Cancer |
PubMed
Reference PMID: 32144252 |
|
LEP
mRNA |
Leptin promotes autophagy in breast cancer microenvironment | Leptin inducesautophagy to promote proliferation, migration, morphological changes, and ERK phosphorylation in triple-negative (MDA-MB-231) breast cancer cells. | Breast Cancer |
PubMed
Reference PMID: 33763424 |
|
SESN2
mRNA |
Stress-inducible mTORC1 brake; SESN2 knockdown diminishes autophagy (?LC3-II, ?p62) in TNBC cells under betulinic acid treatment. | Cytoprotective autophagy: SESN2 loss sensitizes MDA-MB-231 and HS578T TNBC cells to betulinic acid. | Breast Cancer |
PubMed
Reference PMID: 36611970 |