Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
ZC3H12A
mRNA |
RNase MCPIP1; degrades mRNAs of survival genes and can promote pro-apoptotic gene expression. | Acts as tumor suppressor in BC; overexpression triggers apoptosis in some TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 26833120 |
|
CCAR1
mRNA |
Coactivator that augments p53-dependent transcription and is required for chemo-induced apoptosis. | Activation induces apoptosis in TNBC cells via p38/JNK signaling. | Breast Cancer |
PubMed
Reference PMID: 27687593 |
|
TRIAP1
mRNA |
TP53-regulated inhibitor of apoptosis 1; inhibits apoptosome formation and caspase-9 activation. | Upregulated in drug-resistant breast cancer cells, contributing to chemo resistance. | Breast Cancer |
PubMed
Reference PMID: 25998939 |
|
HTR2A
mRNA |
5-HT2A receptor; antagonism can induce apoptosis in breast cancer cells. | HTR2A antagonists induce apoptosis in BC cell lines. | Breast Cancer |
PubMed
Reference PMID: 26768715 |
|
FADD
mRNA |
Adaptor protein that bridges activated death receptors to procaspase-8 at the DISC, promoting extrinsic apoptosis. | Required for TNF?/TRAIL-induced extrinsic apoptosis in TNBC cells; modulates sensitivity to death ligands. | Breast Cancer |
PubMed
Reference PMID: 26733177 |
|
DICER1
mRNA |
Processes miRNAs; loss alters apoptotic miRNA expression leading to reduced apoptosis. | Lower Dicer expression in TNBC than ER+ breast cancers, implying reduced miRNA-mediated apoptotic control. | Breast Cancer |
PubMed
Reference PMID: 27260947 |
|
PAK2
mRNA |
PAK2 phosphorylates caspase-7 (Ser-30/Thr-173/Ser-239) and blocks caspase-7 activation, thereby inhibiting executioner caspase activity (anti-apoptotic effect). | PAK2 upregulation correlates with poorer outcomes and chemoresistance in breast cancer/TNBC and contributes to suppression of apoptosis. | Breast Cancer |
PubMed
Reference PMID: 39803692 |
|
FAP
mRNA |
Fibroblast activation protein alpha (FAP) expressed in tumor stroma promotes tumor-supportive signaling (PI3K/AKT) and can protect tumor cells from apoptosis; FAP targeting disrupts stromal support and increases tumor cell death. | FAP knockdown reduces tumor growth and increases apoptosis in breast cancer models. | Breast Cancer |
PubMed
Reference PMID: 24885257 |
|
CASP8
mRNA |
Initiator caspase in the extrinsic apoptosis pathway; activated at death-inducing signaling complex (DISC) and activates downstream executioner caspases. | Caspase-8 activation mediates extrinsic apoptosis in TNBC models under ER stress and DR5 activation. | Breast Cancer |
PubMed
Reference PMID: 29374147 |
|
TP53BP2
mRNA |
ASPP2 (TP53BP2) stimulates p53-mediated transactivation of pro-apoptotic genes; loss reduces p53-driven apoptosis. | Silencing of ASPP2 promotes proliferation and migration and reduces apoptosis in TNBC cells via PI3K/AKT pathway. | Breast Cancer |
PubMed
Reference PMID: 29568874 |