Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
TP53
mRNA |
Loss of TP53 promotes autophagy and chemoresistance in TNBC | Mutant TP53 enhances survival of TNBC cells via autophagy | Breast Cancer |
PubMed
Reference PMID: 23650262 |
|
TBK1
mRNA |
Serine/threonine kinase that phosphorylates autophagy receptors such as OPTN and regulates selective autophagy. | TBK1 inhibition reduces autophagy and sensitizes TNBC cells to chemotherapy and targeted therapy (MDA-MB-231, xenografts). | Breast Cancer |
PubMed
Reference PMID: 24449872 |
|
TBK1
mRNA |
Serine/threonine kinase that phosphorylates autophagy receptors such as OPTN and regulates selective autophagy. | TBK1 inhibition reduces autophagy and sensitizes TNBC cells to chemotherapy and targeted therapy (MDA-MB-231, xenografts). | Breast Cancer |
PubMed
Reference PMID: 33454423 |
|
MAPK3
mRNA |
K48-linked ubiquitination and proteasomal degradation of ULK1 | MAPK3 (ERK1) signaling directly to autophagy regulation (specifically mitophagy via ULK1) and demonstrates its impact on breast cancer progression. | Breast Cancer |
PubMed
Reference PMID: 33213267 |
|
BNIP3L
mRNA |
Mitophagy receptor (NIX); mediates BNIP3L/NIX-dependent mitophagy. | Exosomal ITGB4 from TNBC cells induces BNIP3L/NIX-dependent mitophagy in CAFs, promoting proliferation/EMT/invasion and tumor growth in co-transplantation models. | Breast Cancer |
PubMed
Reference PMID: 31534187 |
|
GABARAP
mRNA |
Member of Atg8 family; regulates autophagosome maturation and cargo recruitment. | Upregulation of GABARAP enhances autophagy and promotes TNBC progression. Silencing reduces migration and invasion in vitro. | Breast Cancer |
PubMed
Reference PMID: 33591943 |
|
STK11
mRNA |
LKB1 regulates AMPK-mTOR-autophagy signaling in breast cancer | Loss of STK11 promotes tumor growth through impaired autophagy in TNBC | Breast Cancer |
PubMed
Reference PMID: 28696138 |
|
BECN1
mRNA |
Core autophagy regulator; forms complexes with class III PI3K to initiate autophagosome formation. | Beclin1 regulates autophagy-mediated survival in TNBC; loss or suppression sensitizes to chemotherapy. | Breast Cancer |
PubMed
Reference PMID: 22733132 |
|
MTOR
mRNA |
AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis | The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition | Breast Cancer |
PubMed
Reference PMID: 27526942 |
|
USP10
mRNA |
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy. | USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1. | Breast Cancer |
PubMed
Reference PMID: 21962518 |