Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
USP20
mRNA |
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation. | USP20 promotes migration/invasion in breast cancer | Breast Cancer |
PubMed
Reference PMID: 29487085 |
|
HDAC6
mRNA |
Cytoplasmic deacetylase that regulates autophagosome�lysosome fusion and autophagic flux. | Sulforaphane induces autophagy and suppresses TNBC cell growth via inhibition of HDAC6-mediated PTEN activation (MDA-MB-231/468). | Breast Cancer |
PubMed
Reference PMID: 30352240 |
|
DNM2
mRNA |
Dynamin?2 regulates autophagosome formation/ATG9 trafficking; dynamin inhibition impairs autophagy. | In TNBC derivatives (MDA?MB?231?BR3), DNM2 knockdown impairs homologous recombination and increases sensitivity to PARP inhibitors. | Breast Cancer |
PubMed
Reference PMID: 30371505 |
|
SLC7A5
mRNA |
LAT1-mediated essential amino acid uptake activates mTORC1; LAT1 inhibition can reduce mTORC1 signaling and trigger autophagy. | Overexpressed in TNBC; higher LAT1 correlates with poor prognosis and is a therapeutic target in TNBC models. | Breast Cancer |
PubMed
Reference PMID: |
|
HMGB1
mRNA |
Upregulates autophagy via HMGB1�Beclin1 axis; miR-107 targeting HMGB1 reduces autophagy markers (LC3-II) in MDA-MB-231 cells. | Promotes migration/survival; HMGB1 suppression (by miR-107) decreases autophagy and migration in MDA-MB-231 (TNBC). | Breast Cancer |
PubMed
Reference PMID: 30506984 |
|
ATG9A
mRNA |
Only multi-pass transmembrane ATG protein; supplies membrane for autophagosome biogenesis. | ATG9A is overexpressed in TNBC; knockdown reduces autophagy, migration and colony formation, indicating a pro-tumor role. | Breast Cancer |
PubMed
Reference PMID: 30563263 |
|
LGALS8
mRNA |
Galectin-8 senses damaged endomembranes and promotes selective autophagy by recruiting autophagy adaptors to ruptured vesicles. | Dual knockdown of LGALS8 and its ligand ALCAM reduces tumor growth and lung metastasis in TNBC models (MDA?MB?231). | Breast Cancer |
PubMed
Reference PMID: 30905597 |
|
TRIM27
mRNA |
E3 ligase TRIM27 ubiquitinates and destabilizes ULK1, inhibiting autophagy initiation. | Promotes primary tumor growth in breast cancer models; evidence includes 4T1 (TNBC) systems. | Breast Cancer |
PubMed
Reference PMID: 35670107 |
|
PIK3CA
mRNA |
Encodes p110? catalytic subunit of PI3K; regulates PI3K/AKT/mTOR signaling that suppresses autophagy. | PIK3CA mutations alter PI3K/AKT/mTOR signaling; inhibitors restore autophagy and sensitize TNBC to therapy. | Breast Cancer |
PubMed
Reference PMID: |
|
ATG7
mRNA |
Core autophagy E1-like enzyme that mediates LC3/ATG8 lipidation (autophagosome formation). | Higher ATG7 expression associates with better prognosis; ATG7 suppresses proliferation and migration and promotes apoptosis in TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 30988371 |