Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
HMOX1
mRNA |
HMOX-1 confers chemoresistance of breast cancer cells, by preventing autophagy | Enhancing the cytotoxicity and efficacy of doxorubicin during the treatment of breast cancer. | Breast Cancer |
PubMed
Reference PMID: 26722274 |
|
WAC
mRNA |
its depletion in human cells has been shown to induce autophagy | Downregulation of circWAC can increase the sensitivity of TNBC cells to paclitaxel (PTX) in vitro and in vivo. | Breast Cancer |
PubMed
Reference PMID: 33648498 |
|
ATG5
mRNA |
Core autophagy-related protein essential for autophagosome elongation. | ATG5 are targets of miR-181a. Inhibition of miR-181a expression led to attenuation of TNBC stemness and an increase in autophagy flux. | Breast Cancer |
PubMed
Reference PMID: 35029026 |
|
WDFY3
mRNA |
Scaffold/adaptor for selective macroautophagy (aggrephagy); facilitates p62-dependent cargo degradation. | Predict tumor recurrence and metastasis | Breast Cancer |
PubMed
Reference PMID: 33614483 |
|
ULK1
mRNA |
Initiator kinase of autophagy (ULK1-ATG13-FIP200-ATG101 complex). Pharmacologic activation triggers autophagy. | ULK1 activation (LYN-1604) induces autophagy-associated cell death and suppresses TNBC growth in vitro and in vivo. | Breast Cancer |
PubMed
Reference PMID: 28553505 |
|
ATP2A2
mRNA |
SERCA2 inhibition perturbs ER Ca2+ homeostasis, activating CaMKK�AMPK�mTOR signaling and inducing excessive autophagy. | Small-molecule RL71 targeting SERCA2 triggers autophagy-dependent cell death and suppresses tumor growth/metastasis in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 36561988 |
|
GABARAPL1
mRNA |
ATG8 family protein associated with autophagic vesicles; regulates autophagic flux. | Promotes TNBC proliferation and metastasis partly via MTDH; suggested as therapeutic target (cell and animal models). | Breast Cancer |
PubMed
Reference PMID: 29088804 |
|
RPTOR
mRNA |
Scaffold of mTORC1; activation suppresses autophagy via ULK1 inhibition. | In TNBC cells, RPTOR inhibition overcame resistance to EGFR inhibition (gefitinib), reducing viability and signaling. | Breast Cancer |
PubMed
Reference PMID: 29344641 |
|
FOXO3
mRNA |
Luteolin treatments suppress SGK1, which allows FOXO3a to move into the nucleus and upregulate BNIP3; this triggers autophagy | Luteolin induces autophagy in TNBC via SGK1-FOXO3a-BNIP3 signaling | Breast Cancer |
PubMed
Reference PMID: 37346292 |
|
USP20
mRNA |
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation. | USP20 promotes migration/invasion in breast cancer | Breast Cancer |
PubMed
Reference PMID: 32943575 |