Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
CSNK2A1
mRNA |
Casein kinase II alpha (CK2?) phosphorylates targets to promote survival signaling and suppress apoptosis. | Overexpressed in breast cancer (including TNBC); CK2 inhibition induces apoptosis. | Breast Cancer |
PubMed
Reference PMID: 36114992 |
|
CASP9
mRNA |
Initiator caspase of the intrinsic (mitochondrial) apoptosis pathway activated by Apaf-1 in the apoptosome; activates executioner caspases like caspase-3. | CASP9 expression associates with prognosis in breast cancer; restoration of caspase-9 can suppress metastatic behavior in TNBC models in recent studies. | Breast Cancer |
PubMed
Reference PMID: 36199443 |
|
PDCD10
mRNA |
Scaffolding component (CCM3); can promote apoptosis through stress kinases in some contexts. | Loss increases chemoresistance in breast cancer, suggesting a role in apoptosis and therapy response. | Breast Cancer |
PubMed
Reference PMID: 30408026 |
|
BCL2L14
mRNA |
BCL2L14 (BCL-G) is a BCL-2 family member with pro-apoptotic BH3-like activity in certain contexts, promoting mitochondrial apoptosis when active. | BCL2L14 fusions/alterations have been observed in aggressive breast cancers; linked to therapy resistance features. | Breast Cancer |
PubMed
Reference PMID: 32321829 |
|
CASP2
mRNA |
Caspase-2 acts as a stress-response initiator caspase involved in DNA damage-induced apoptosis and can function upstream of mitochondrial pathways. | Altered CASP2 expression associates with prognosis in breast cancer/TNBC; functional context varies by study. | Breast Cancer |
PubMed
Reference PMID: 37093683 |
|
CCAR2
mRNA |
Inhibits SIRT1 to stabilize p53 and promote p53-mediated apoptosis; also coactivates ER?/PEA3 under some contexts. | Dual role in breast cancer; linked to prognosis and can modulate apoptosis in BC. | Breast Cancer |
PubMed
Reference PMID: 37524873 |
|
BCL2L1
mRNA |
BCL2L1 (BCL-xL) is an anti-apoptotic Bcl-2 family protein that sequesters pro-apoptotic BH3-only proteins and Bax/Bak to prevent MOMP and apoptosis. | Overexpression in TNBC contributes to chemoresistance; BCL-xL inhibition enhances apoptosis and chemosensitivity. | Breast Cancer |
PubMed
Reference PMID: 38898061 |
|
CASP10
mRNA |
Initiator caspase in extrinsic apoptosis (death receptor pathway). | Expression observed in TNBC; functional studies limited in last 10 years but expression associated with apoptosis responses. | Breast Cancer |
PubMed
Reference PMID: 40806590 |
|
HIF1A
mRNA |
Hypoxia-activated HIF-1? transcriptionally induces BNIP3/NIX to promote mitophagy and hypoxia-induced autophagy. | High HIF-1?/BNIP3-axis activity associates with aggressive TNBC biology; BNIP3 loss (with hypoxia/HIF-1? signaling) promotes TNBC progression and metastasis. | Breast Cancer |
PubMed
Reference PMID: 26232272 |
|
BNIP3
mRNA |
HIF-1?�induced mitophagy receptor; promotes BNIP3/NIX-dependent mitophagy and hypoxia-induced autophagy. | BNIP3 loss promotes TNBC progression and metastasis under hypoxia; BNIP3 axis is clinically relevant in TNBC. | Breast Cancer |
PubMed
Reference PMID: 26232272 |