Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
BIRC2
mRNA |
Encodes cIAP1 which ubiquitinates caspases and inhibits apoptosis. | Overexpressed in TNBC and promotes chemoresistance. | Breast Cancer |
PubMed
Reference PMID: 33673050 |
|
BIRC3
mRNA |
Encodes cIAP2; inhibits caspases and activates NF-?B pro-survival signaling. | Overexpressed in TNBC contributing to apoptosis resistance. | Breast Cancer |
PubMed
Reference PMID: 33673050 |
|
TRPC5
mRNA |
Calcium channel; increased Ca2+ influx activates survival pathways and drug-resistance mechanisms. | promotes drug resistance in breast carcinoma via CaMKK?/AMPK?/mTOR pathway | Breast Cancer |
PubMed
Reference PMID: 33426511 |
|
RIPK1
mRNA |
Mediates death-receptor signaling; can trigger caspase-8-dependent apoptosis or necroptosis depending on context. | Restoring RIPK1 can trigger apoptosis in TNBC models and suppress progression. | Breast Cancer |
PubMed
Reference PMID: 33980862 |
|
XIAP
mRNA |
X-linked inhibitor of apoptosis protein (XIAP) binds and inhibits active caspases-3, -7, and -9, blocking apoptosis; also has E3 ligase activity that promotes survival signaling. | Higher XIAP expression in invasive breast cancer is associated with shorter survival and chemotherapy resistance. | Breast Cancer |
PubMed
Reference PMID: 34199946 |
|
DFFB
mRNA |
Caspase-activated DNase (CAD/DFF40) executes internucleosomal DNA fragmentation and chromatin condensation downstream of caspase-3. | DFF40-iRGD chimeric protein induces apoptosis and cytotoxicity in TNBC cells and reduces tumor growth in models. | Breast Cancer |
PubMed
Reference PMID: 34482510 |
|
AIFM2
mRNA |
AIFM2 (FSP1) is a mitochondrial oxidoreductase that can induce caspase-independent apoptosis and also functions in ferroptosis suppression via CoQ regeneration; implicated in oncogenic ceRNA axes affecting cell survival. | AIFM2 upregulation linked to tumor progression in breast cancer (reported in HER2+ contexts). | Breast Cancer |
PubMed
Reference PMID: 34668628 |
|
PLSCR1
mRNA |
Phospholipid scramblase 1; nuclear PLSCR1 modulates STAT signaling and survival pathways. | potentially involved in T cell signaling under regulation of B7 family proteins, a be a potential target for breast cancer immunotherapy. | Breast Cancer |
PubMed
Reference PMID: 27622076 |
|
DFFA
mRNA |
ICAD (DFFA) is cleaved by caspase-3 to release DFFB/CAD, enabling DNA fragmentation during apoptosis. | Thymoquinone treatment upregulated DFFA mRNA in MDA-MB-231 and MDA-MB-468 cells, correlating with apoptosis induction. | Breast Cancer |
PubMed
Reference PMID: 35631261 |
|
GPER1
mRNA |
G-protein coupled estrogen receptor; loss/activation can trigger JNK/p53/Noxa-mediated mitochondrial apoptosis. | High GPER1 correlates with poor prognosis in TNBC; modulation affects apoptosis. | Breast Cancer |
PubMed
Reference PMID: 36042244 |