Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
TNFRSF1A
mRNA |
TNF receptor 1 mediates TNF? signaling leading to either NF-?B-driven survival or assembly of death-inducing complexes that activate caspase-8 and extrinsic apoptosis. | TNFRSF1A expression links to NF-?B activation in breast cancer and can modulate apoptosis vs survival depending on context. | Breast Cancer |
PubMed
Reference PMID: 29621649 |
|
BCL2
mRNA |
Anti-apoptotic Bcl-2 family protein that sequesters pro-apoptotic BH3-only proteins and prevents mitochondrial outer membrane permeabilization (MOMP). | Bcl-2 inhibition sensitizes TNBC cells to chemotherapy; Bcl-2 expression patterns are subtype-dependent in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 29876007 |
|
CASP7
mRNA |
Executioner caspase activated downstream of initiator caspases; executes apoptosis by cleaving cellular substrates. | Low cleaved caspase-7 levels associate with unfavorable outcome across breast cancers; caspase-7 activity impacts response to therapy. | Breast Cancer |
PubMed
Reference PMID: 30069746 |
|
SIRT2
mRNA |
NAD+-dependent deacetylase; modulates apoptosis via deacetylation of targets and ROS responses. | Often amplified/overexpressed in TNBC and promotes survival; SIRT2 loss sensitizes cells to ROS-induced apoptosis. | Breast Cancer |
PubMed
Reference PMID: 27503926 |
|
HRK
mRNA |
BH3-only pro-apoptotic Bcl-2 family member; binds Bcl-2/Bcl-xL to release Bax/Bak and promote mitochondrial apoptosis. | Breast Cancer |
PubMed
Reference PMID: 30774992 |
|
|
AIFM3
mRNA |
Mitochondrial oxidoreductase similar to AIF; upon release can mediate caspase-independent apoptosis via chromatin condensation and DNA fragmentation. | Overexpression in breast cancer linked to metastasis and poor prognosis. | Breast Cancer |
PubMed
Reference PMID: 31088422 |
|
AKT1
mRNA |
AKT1 (PKB?) is a serine/threonine kinase that promotes cell survival by phosphorylating/inactivating pro-apoptotic factors (BAD, FOXO), inhibiting caspase activation and promoting MDM2-mediated p53 degradation; isoform-specific effects exist in breast cancer. | AKT1 activation impairs apoptosis and promotes tumor initiation in breast cancer; isoform-specific roles affect therapy response in TNBC. | Breast Cancer |
PubMed
Reference PMID: 31752925 |
|
CASP3
mRNA |
Executioner caspase that cleaves multiple substrates to execute apoptosis following activation by initiator caspases. | Cleaved (active) caspase-3 in TNBC correlates with chemotherapy response and can be a marker of apoptosis. | Breast Cancer |
PubMed
Reference PMID: 31949833 |
|
TP53
mRNA |
TP53 encodes p53, a transcription factor that activates pro-apoptotic genes (BAX, PUMA/BBC3, NOXA) in response to DNA damage and stress, inducing mitochondrial apoptosis and cell-cycle arrest. | TP53 is frequently mutated in breast cancer, especially TNBC; mutant p53 alters apoptosis and is associated with therapy response and prognosis. | Breast Cancer |
PubMed
Reference PMID: 32061310 |
|
DLC1
mRNA |
Tumor-suppressor RhoGAP activity; restoration of DLC1 expression reduces pro-survival signaling and promotes apoptosis. | Curcumin restored DLC1 expression and promoted apoptosis in TNBC cell lines and xenografts. | Breast Cancer |
PubMed
Reference PMID: 32725802 |