Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
TGFB1
mRNA |
Part of IL?6?TGF??1?HLF axis from TAMs; HLF upregulates GGT1 to boost GSH, conferring ferroptosis resistance. | Promotes ferroptosis resistance and malignant progression in TNBC via TAM?derived IL?6/TGF??1 signaling. | Breast Cancer |
PubMed
Reference PMID: 34991659 |
|
IL6
mRNA |
TNBC?secreted IL?6 activates TAMs to secrete TGF??1 ? activates HLF in tumor cells ? upregulates GGT1 ? suppresses ferroptosis. | Confers ferroptosis resistance; promotes progression and chemoresistance. | Breast Cancer |
PubMed
Reference PMID: 34991659 |
|
P4HB
mRNA |
Protein disulfide isomerase (encoded by P4HB) is required for erastin-induced ferroptosis in MDA-MB-231 TNBC cells by promoting lipid ROS accumulation. | Facilitates ferroptotic death upon erastin; PDI inhibition reduces ferroptosis in TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 30367042 |
|
HMOX1
mRNA |
HO-1 (HMOX1) axis modulates ferroptosis; HO-1-dependent ferroptosis reported in TNBC cells | HO-1 upregulation can mediate ferroptotic cell death (e.g., HCL-23 triggers HO-1-dependent ferroptosis in TNBC cells) | Breast Cancer |
PubMed
Reference PMID: 37110625 |
|
SIRT3
mRNA |
Drives autophagy?dependent ferroptosis by promoting BECN1?SLC7A11 complex formation (AMPK/mTOR axis). | Enhances ferroptosis and anticancer activity in breast cancer models including TNBC cell lines. | Breast Cancer |
PubMed
Reference PMID: 37196680 |
|
SOCS1
mRNA |
Ferroptosis driver that downregulates GPX4/xCT, elevating lipid peroxidation. | Overexpression induces ferroptosis, inhibits growth and cisplatin resistance in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 37665951 |
|
ACSL4
mRNA |
Ligates AA/AdA to PUFA?CoA enabling incorporation into phospholipids, creating ferroptosis?prone membranes. | Required for thrombin?induced ferroptosis via cPLA2?/ACSL4 signaling in TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 37939630 |
|
TP53
mRNA |
Wild?type p53 can repress SLC7A11 to promote ferroptosis; mutant p53 can block ferroptosis. | Mutant p53 protects TNBC from ferroptosis; depletion restores ferroptotic sensitivity. | Breast Cancer |
PubMed
Reference PMID: 38354236 |
|
ALOX12
mRNA |
12?lipoxygenase catalyzes PUFA?PE peroxidation to drive ferroptosis. | Upregulated by SBFI26 in TNBC cells; promotes lipid peroxidation and ferroptotic death. | Breast Cancer |
PubMed
Reference PMID: 38516826 |
|
ALOXE3
mRNA |
Epidermal lipoxygenase implicated in lipid peroxide generation. | Upregulated by SBFI26 alongside other LOX genes; associated with ferroptosis induction in TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 38516826 |