Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
VDAC1
mRNA |
DYNLT1 stabilizes the voltage-dependent anion channel 1 (VDAC1) by hindering E3 ligase Parkin-mediated VDAC1 ubiquitination and degradation. | The protein DYNLT1 stabilizes VDAC1 by preventing Parkin-mediated degradation, enhancing mitochondrial metabolism and fueling tumor proliferation, especially in TNBC subtypes. | Breast Cancer |
PubMed
Reference PMID: 37280526 |
|
OPTN
mRNA |
Selective autophagy receptor (cargo adaptor); regulates degradation pathways and intersects with TGF-? signaling. | OPTN limits metastasis in TNBC; loss of OPTN enhances metastatic behavior in cell and mouse models. | Breast Cancer |
PubMed
Reference PMID: 36823950 |
|
DNM1L
mRNA |
Mitochondrial fission GTPase; promotes mitophagy by enabling segregation of damaged mitochondria. | ELK3�DRP1 axis determines chemosensitivity of TNBC; DRP1 activity linked to drug response. | Breast Cancer |
PubMed
Reference PMID: 37422450 |
|
ATG13
mRNA |
Core ULK1-complex subunit initiating autophagosome formation; release of miR-224-5p suppression increases ATG13/ULK1 axis activity. | Exosomal circEGFR promotes ATG13/ULK1-driven autophagy to enhance malignant progression and metastasis in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 38280941 |
|
STUB1
mRNA |
METTL3-mediated m6A modification increases STUB1 (CHIP), which inhibits autophagy in TNBC cells. | Inhibition of autophagy via elevated STUB1 contributes to anti-tumor effects; modulation of STUB1 reduces TNBC cell growth. | Breast Cancer |
PubMed
Reference PMID: 38823344 |
|
TFEB
mRNA |
Master transcription factor driving autophagy�lysosome gene program; activated/nuclear TFEB elevates autophagic flux. | TRIM25-mediated neddylation activates TFEB, inducing cytoprotective autophagy that desensitizes TNBC cells to paclitaxel. | Breast Cancer |
PubMed
Reference PMID: 38926803 |
|
TSG101
mRNA |
ESCRT-I component required for autophagosome maturation/closure and cargo sorting (context-dependent). | Mammary tumors induced by Tsg101 loss display triple?negative phenotype; implicates TSG101 in TNBC biology. | Breast Cancer |
PubMed
Reference PMID: 40624726 |
|
PIK3C3
mRNA |
Class III PI3K (VPS34) generates PI3P to initiate autophagosome formation; pharmacologic inhibition blocks autophagy. | In TNBC cell lines, VPS34 inhibition with SAR405 altered immunogenic signaling and activated NF-?B/CXCL10; highlights autophagy�s role in TNBC response. | Breast Cancer |
PubMed
Reference PMID: 40691137 |
|
ATP7A
mRNA |
Copper-exporting ATPase ATP7A reduces intracellular copper and can blunt cuproptosis by exporting toxic copper. | ATP7A supports copper-dependent enzymes (e.g., LOX) that promote invasion/metastasis in breast cancer; modulating ATP7A or copper levels affects metastasis and cuproptosis sensitivity. | Breast Cancer |
PubMed
Reference PMID: 30890638 |
|
CDKN2A
mRNA |
CDKN2A (p16INK4a/p14ARF locus) was associated with modifiers of cuproptosis in genomic screens and may affect cell-state dependent sensitivity. | CDKN2A status may modulate cuproptosis susceptibility and therapy response in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 39976173 |