Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-495-3p
miRNA |
miR-495-3p mimics downregulate GRP78 and reduce p?AKT/mTOR signaling (autophagy-related pathway) in a TNBC drug-resistance model. | Sensitizes TNBC cells to pirarubicin and reverses drug resistance. | Breast Cancer |
PubMed
Reference PMID: 34935899 |
|
hsa-miR-181a-5p
miRNA |
Suppresses autophagy via direct repression of ATG5 and/or ATG2B. | Reduces autophagy, increasing cancer stemness and aggressive features in TNBC. | Breast Cancer |
PubMed
Reference PMID: 35029026 |
|
hsa-miR-30a-5p
miRNA |
miR-30a-3p negatively regulated autophagy by autophagy related 12 (Atg12) | Altered mammary structure in the involution of the mammary glands of mice, which was indicative of alteration in mammary remodeling | Breast Cancer |
PubMed
Reference PMID: 37762652 |
|
hsa-miR-4295
miRNA |
Targets ITPR1 to suppress autophagy; RMST lncRNA sponges miR-4295, restoring ITPR1 and increasing autophagic flux (?LC3-II/I, ?p62). | miR-4295 promotes proliferation/migration; RMST/ITPR1 counteracts this and suppresses TNBC progression via pro-autophagic signaling. | Breast Cancer |
PubMed
Reference PMID: 40287640 |
|
hsa-miR-27a-3p
miRNA |
Promotes autophagy by targeting/relieving BNIP3; CAF exosomal circFOXO1 lowers miR-27a-3p, increasing BNIP3 and autophagy during radiotherapy. | Increases radioresistance and pro?tumor traits in TNBC (MDA?MB?231); autophagy inhibition (3?MA) weakens these effects. | Breast Cancer |
PubMed
Reference PMID: 40784956 |
|
hsa-miR-25-3p
miRNA |
Upregulation reduces autophagy by suppressing ULK1, leading to chemoresistance (reported in BC models). | Reduced autophagy; increased chemoresistance in breast cancer models. | Breast Cancer |
PubMed
Reference PMID: |
|
miR-153
miRNA |
Reduces cell ferroptosis via circ_0000643/miR-153/SLC7A11 axis | Inhibits ferroptosis and promotes progression | Breast Cancer |
PubMed
Reference PMID: 37591453 |
|
miR-335-5p
miRNA |
Regulates GPX4 via Sp1 transcription factor | Induces ferroptosis and inhibits progression | Breast Cancer |
PubMed
Reference PMID: 38866351 |
|
miR-128-3p
miRNA |
Targets CD98hc, induces ferroptosis | Promotes ferroptosis and reduces tumor burden | Breast Cancer |
PubMed
Reference PMID: 38734268 |
|
miR-376c-3p
miRNA |
Targets SLC7A11 to regulate ferroptosis | Inhibits ferroptosis and supports tumor growth | Breast Cancer |
PubMed
Reference PMID: 38318853 |