Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-96-5p
miRNA |
Targets FOXO1, PTEN and others (PI3K/AKT) and inhibits apoptosis | Oncogenic; promotes proliferation, invasion and chemoresistance | Breast Cancer |
PubMed
Reference PMID: 28588711 |
|
hsa-miR-221-3p
miRNA |
Targets p27^Kip1; associated with autophagic cell death signaling in MCF-7 context (reviews). | Confers tamoxifen resistance in ER+ breast cancer via p27^Kip1 downregulation; autophagy implicated. | Breast Cancer |
PubMed
Reference PMID: 18708351 |
|
hsa-miR-222-3p
miRNA |
Targets p27^Kip1; linked with autophagy modulation in MCF-7 per reviews. | Confers tamoxifen resistance in ER+ breast cancer via p27^Kip1 downregulation; autophagy implicated. | Breast Cancer |
PubMed
Reference PMID: 18708351 |
|
hsa-miR-200c-3p
miRNA |
Inhibits irradiation?induced autophagy by targeting UBQLN1; enhances radiosensitivity. | In MDA?MB?231/BT549 (TNBC) cells, miR?200c overexpression reduces autophagy and increases radiosensitivity. | Breast Cancer |
PubMed
Reference PMID: 25044403 |
|
hsa-miR-129-5p
miRNA |
Attenuates irradiation?induced autophagy by directly targeting HMGB1; increases radiosensitivity. | In MDA?MB?231 (TNBC) cells, overexpression inhibits autophagy and sensitizes to radiation. | Breast Cancer |
PubMed
Reference PMID: 26720492 |
|
hsa-miR-21-5p
miRNA |
Knockdown increases autophagy via inhibition of PI3K/AKT/mTOR (?Beclin-1, ?LC3-II), enhancing endocrine-therapy-induced autophagic cell death. | Sensitizes ER+ breast cancer cells to tamoxifen/fulvestrant; promotes autophagy when inhibited. | Breast Cancer |
PubMed
Reference PMID: 26796263 |
|
hsa-miR-20b-5p
miRNA |
Suppresses autophagy by targeting RB1CC1/FIP200, reducing LC3-II (shown in MDA-MB-231). | Autophagy inhibition supports proliferation/survival in the TNBC cell line MDA?MB?231. | Breast Cancer |
PubMed
Reference PMID: 26829385 |
|
hsa-miR-96-5p
miRNA |
Inhibits autophagy by directly targeting FOXO1; reduces LC3-II and increases p62 in MDA-MB-231 under starvation | Pro-tumorigenic: enhances proliferation, migration, and invasion; suppresses apoptosis in MDA-MB-231 | Breast Cancer |
PubMed
Reference PMID: 28588711 |
|
hsa-miR-20a-5p
miRNA |
Inhibits the basal and nutrient starvation-induced autophagic flux and lysosomal proteolytic activity | miR-20a promotes tumor initiation and tumor growth. | Breast Cancer |
PubMed
Reference PMID: 28628113 |
|
hsa-miR-23a-3p
miRNA |
Promotes autophagy and inhibits apoptosis via XIAP/Autophagy pathway in breast cancer cells. | Pro-survival autophagy; may contribute to therapy resistance. | Breast Cancer |
PubMed
Reference PMID: 28671686 |