Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-331-3p
miRNA |
Strongly associated with necroptosis and breast cancer prognosis. | Poor prognosis; enriched in transcriptional regulation and membrane trafficking genes. | Breast Cancer |
PubMed
Reference PMID: 35371342 |
|
hsa-miR-181c-5p
miRNA |
Targets BCL2 in LINC00665/miR-181c-5p/BCL2 axis for necroptosis regulation. | Promotes necroptosis; linked to poor outcomes in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 35251139 |
|
hsa-miR-216b-5p
miRNA |
Reexpression sensitizes trastuzumab-resistant cells by inducing necroptosis through STAT1, IRF9, and PKR. | Reduces drug resistance; promotes necroptosis in HER2+ breast cancer. | Breast Cancer |
PubMed
Reference PMID: 37529418 |
|
miR-141-3p
miRNA |
Modulates RIPK1/RIPK3/MLKL axis, regulating necroptosis by inhibiting downstream signaling pathways. | Promotes tumor progression by targeting key tumor suppressors; associated with metastasis and poor prognosis. | Breast Cancer |
PubMed
Reference PMID: 35371342 |
|
miR-148a-3p
miRNA |
Influences necroptosis by targeting inflammatory mediators involved in cell death pathways. | Acts as a tumor suppressor by inhibiting oncogene expression; downregulation linked to aggressive phenotypes. | Breast Cancer |
PubMed
Reference PMID: 36965898 |
|
miR-200a-5p
miRNA |
Regulates oxidative stress and necroptotic pathways by modulating MLKL phosphorylation and ROS production. | Inhibits epithelial-to-mesenchymal transition (EMT); its deregulation is linked to BRCA metastasis. | Breast Cancer |
PubMed
Reference PMID: |
|
miR-223-3p
miRNA |
Affects necroptosis by targeting key necroptotic proteins like RIPK3 and MLKL, modulating inflammation-induced cell death | Plays a dual role; promotes or inhibits BRCA progression depending on context and targets. Identified as therapeutic. | Breast Cancer |
PubMed
Reference PMID: 35371342 |
|
miR-425-5p
miRNA |
Impacts necroptotic signaling by altering the expression of RIPK1 and related mediators. | Functions as an oncogenic miRNA; promotes BRCA cell proliferation and inhibits apoptosis. | Breast Cancer |
PubMed
Reference PMID: |
|
miR-204-5p
miRNA |
Regulates the SLC31A1 expression, part of the LINC01614/miR-204-5p/SLC31A1 axis | Associated with immune infiltration and poor prognosis | Breast Cancer |
PubMed
Reference PMID: 37884650 |
|
miR-200c-3p
miRNA |
Regulates ZFPM2 and CFL2 | Associated with TNBC prognosis and immune infiltration | Breast Cancer |
PubMed
Reference PMID: 38601669 |