Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
ATP7A
mRNA |
Copper-exporting ATPase ATP7A reduces intracellular copper and can blunt cuproptosis by exporting toxic copper. | ATP7A supports copper-dependent enzymes (e.g., LOX) that promote invasion/metastasis in breast cancer; modulating ATP7A or copper levels affects metastasis and cuproptosis sensitivity. | Breast Cancer |
PubMed
Reference PMID: 30890638 |
|
CDKN2A
mRNA |
CDKN2A (p16INK4a/p14ARF locus) was associated with modifiers of cuproptosis in genomic screens and may affect cell-state dependent sensitivity. | CDKN2A status may modulate cuproptosis susceptibility and therapy response in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 39976173 |
|
FDX1
mRNA |
FDX1 (ferredoxin 1) is a core cuproptosis regulator that promotes protein lipoylation and sensitizes cells to copper-induced DLAT oligomerization and proteotoxic stress. | In TNBC models, FDX1 activity/state is linked to cuproptosis sensitivity and tumor growth: AKT1 phosphorylation of FDX1 was reported to mediate cuproptosis resistance in TNBC, and FDX1 knockdown reduced tumor growth and affected CD8?? T-cell responses. | Breast Cancer |
PubMed
Reference PMID: 40911146 |
|
DLAT
mRNA |
lipoylated and, upon copper binding/oligomerization, undergoes toxic aggregation that is central to cuproptosis execution. | targeting DLAT-dependent processes sensitizes TNBC cells to copper ionophores. | Breast Cancer |
PubMed
Reference PMID: 39460738 |
|
LIPT1
mRNA |
Required for protein lipoylation and the DLAT-dependent proteotoxic aggregation that defines cuproptosis. | Multiple bioinformatic and review papers report differential expression or prognostic associations of these genes in breast cancer / TNBC and propose that their expression/state determines cuproptosis susceptibility; experimental TNBC validation is emerging. | Breast Cancer |
PubMed
Reference PMID: 37853210 |
|
DLD
mRNA |
Required for protein lipoylation and the DLAT-dependent proteotoxic aggregation that defines cuproptosis. | Multiple bioinformatic and review papers report differential expression or prognostic associations of these genes in breast cancer / TNBC and propose that their expression/state determines cuproptosis susceptibility; experimental TNBC validation is emerging. | Breast Cancer |
PubMed
Reference PMID: 37853210 |
|
PDHA1
mRNA |
Required for protein lipoylation and the DLAT-dependent proteotoxic aggregation that defines cuproptosis. | Multiple bioinformatic and review papers report differential expression or prognostic associations of these genes in breast cancer / TNBC and propose that their expression/state determines cuproptosis susceptibility; experimental TNBC validation is emerging. | Breast Cancer |
PubMed
Reference PMID: 37853210 |
|
ATP7B
mRNA |
Copper efflux pump ATP7B modulates cellular copper homeostasis and can decrease cuproptosis susceptibility. | Reported in pan-cancer/cuproptosis signatures and may contribute to therapy resistance via copper handling in breast tumors. | Breast Cancer |
PubMed
Reference PMID: 37853210 |
|
SLC31A1
mRNA |
Copper importer (CTR1) increases cellular copper uptake, promoting susceptibility to cuproptosis when mitochondrial lipoylated proteins are overloaded. | Upregulated in breast cancer and associated with worse prognosis; part of proposed LINC01640/miR-204-5p?SLC31A1 cuproptosis axis. | Breast Cancer |
PubMed
Reference PMID: 37884650 |
|
LINC01614
lncRNA |
Regulates SLC31A1 expression as part of the LINC01614/miR-204-5p/SLC31A1 axis | Associated with poor prognosis and immune infiltration | Breast Cancer |
PubMed
Reference PMID: 37884650 |