Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
NEAT1
lncRNA |
NEAT1 acts as a ceRNA to promote ferroptosis. It sponges miR-362-3p to upregulate MIOX, which raises ROS and depletes GSH, thereby enhancing erastin/RSL3-induced ferroptosis. | NEAT1 is pro-tumorigenic in BC. It promotes cell proliferation, migration, invasion, and metastasis; knockdown of NEAT1 suppresses these malignant phenotypes. | Breast Cancer |
PubMed
Reference PMID: 32801860 |
|
KCNQ1OT1
lncRNA |
KCNQ1OT1 epigenetically inhibits ferroptosis. It recruits the methyltransferase MLL4 to the TRABD promoter, increasing H3K4 methylation and TRABD expression. Inhibition of KCNQ1OT1 (e.g. by ZC3H13-mediated m6A) restores ferroptosis. | KCNQ1OT1 drives chemoresistance and growth in TNBC. Its activation of the TRABD axis promotes doxorubicin resistance; silencing KCNQ1OT1 (by ZC3H13) suppresses proliferation and induces ferroptosis in TNBC. | Breast Cancer |
PubMed
Reference PMID: 40000487 |
|
P53RRA
lncRNA |
Promotes ferroptosis and apoptosis by displacing p53 from G3BP1 complex, increasing nuclear retention of p53 | Tumor suppressor role; low expression correlates with poor survival | Breast Cancer |
PubMed
Reference PMID: 29588351 |
|
DSCAM-AS1
lncRNA |
Inhibits erastin-induced ferroptosis via m6A-modification, enhancing SLC7A11 stability | Promotes progression; overexpression indicates poor prognosis | Breast Cancer |
PubMed
Reference PMID: 38833042 |
|
LINC00152
lncRNA |
Blocks tamoxifen-induced ferroptosis by destabilizing PDE4D, increasing cAMP/Ca2+ levels, and generating ROS | Confers tamoxifen resistance; inhibition restores ferroptosis and sensitizes to treatment | Breast Cancer |
PubMed
Reference PMID: 38879508 |
|
LncFASA
lncRNA |
Increases lipid peroxidation and disrupts ROS homeostasis by inhibiting PRDX1 activity | Impaired growth of triple-negative breast cancer; high expression indicates better survival | Breast Cancer |
PubMed
Reference PMID: 37955780 |
|
PTPRG-AS1
lncRNA |
Inhibits ferroptosis via miR-376c-3p/SLC7A11 axis | Promotes triple-negative breast cancer development | Breast Cancer |
PubMed
Reference PMID: 38318853 |
|
HCP5
lncRNA |
Regulating GPX4 expression and lipid ROS level | Inhibits ferroptosis | Breast Cancer |
PubMed
Reference PMID: 36980766 |
|
LncFASA
lncRNA |
Binds to PRDX1 and inhibits its peroxidase activity | Promotes cancer ferroptosis | Breast Cancer |
PubMed
Reference PMID: 36938678 |
|
LINC00460
lncRNA |
MIR320A-MAL2 axis | Inhibits ferroptosis | Breast Cancer |
PubMed
Reference PMID: 37955780 |