Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
ZEB1
mRNA |
Oxidative stress�induced acetylation (K1108) drives a hybrid EMT state that establishes NADPH?driven redox capacity to circumvent ferroptosis. | Promotes ferroptosis resistance and metastasis in TNBC; targeting this axis exposes a vulnerability. | Breast Cancer |
PubMed
Reference PMID: 40850192 |
|
PTGS2
mRNA |
PTGS2 (COX-2) is commonly upregulated during ferroptosis and is widely used as a transcriptional biomarker of ferroptotic lipid peroxidation (marker, not causal). | Upregulated PTGS2 confirms ferroptosis in TNBC cells (e.g., after GPX4 knockdown or erastin-based strategies). | Breast Cancer |
PubMed
Reference PMID: 31464035 |
|
PTGS2
mRNA |
PTGS2 (COX-2) is commonly upregulated during ferroptosis and is widely used as a transcriptional biomarker of ferroptotic lipid peroxidation (marker, not causal). | Upregulated PTGS2 confirms ferroptosis in TNBC cells (e.g., after GPX4 knockdown or erastin-based strategies). | Breast Cancer |
PubMed
Reference PMID: 33014355 |
|
P53RRA
lncRNA |
Promotes ferroptosis and apoptosis by displacing p53 from G3BP1 complex, increasing nuclear retention of p53 | Tumor suppressor role; low expression correlates with poor survival | Breast Cancer |
PubMed
Reference PMID: 29588351 |
|
DSCAM-AS1
lncRNA |
Inhibits erastin-induced ferroptosis via m6A-modification, enhancing SLC7A11 stability | Promotes progression; overexpression indicates poor prognosis | Breast Cancer |
PubMed
Reference PMID: 38833042 |
|
LINC00152
lncRNA |
Blocks tamoxifen-induced ferroptosis by destabilizing PDE4D, increasing cAMP/Ca2+ levels, and generating ROS | Confers tamoxifen resistance; inhibition restores ferroptosis and sensitizes to treatment | Breast Cancer |
PubMed
Reference PMID: 38879508 |
|
LncFASA
lncRNA |
Increases lipid peroxidation and disrupts ROS homeostasis by inhibiting PRDX1 activity | Impaired growth of triple-negative breast cancer; high expression indicates better survival | Breast Cancer |
PubMed
Reference PMID: 37955780 |
|
PTPRG-AS1
lncRNA |
Inhibits ferroptosis via miR-376c-3p/SLC7A11 axis | Promotes triple-negative breast cancer development | Breast Cancer |
PubMed
Reference PMID: 38318853 |
|
HCP5
lncRNA |
Regulating GPX4 expression and lipid ROS level | Inhibits ferroptosis | Breast Cancer |
PubMed
Reference PMID: 36980766 |
|
LncFASA
lncRNA |
Binds to PRDX1 and inhibits its peroxidase activity | Promotes cancer ferroptosis | Breast Cancer |
PubMed
Reference PMID: 36938678 |