Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
PRKAA2
mRNA |
AMPK activation (by CAPE) promotes ROS/lipid peroxidation and downregulates GPX4/ferritin, inducing ferroptosis. | Activation of AMPK triggers ferroptosis and suppresses TNBC growth in cell/xenograft models. | Breast Cancer |
PubMed
Reference PMID: 39729481 |
|
PRKAA1
mRNA |
AMPK activation (by CAPE) promotes ROS/lipid peroxidation and downregulates GPX4/ferritin, inducing ferroptosis. | Activation of AMPK triggers ferroptosis and suppresses TNBC growth in cell/xenograft models. | Breast Cancer |
PubMed
Reference PMID: 39729481 |
|
EGFR
mRNA |
Cold atmospheric plasma (CAP) modulates EGFR Tyr1068 phosphorylation and potentiates erastin?induced lipid peroxidation/ROS, enhancing ferroptosis. | Sensitizes TNBC cells to ferroptosis and inhibits growth in vitro/in vivo models. | Breast Cancer |
PubMed
Reference PMID: 39781456 |
|
SLC38A1
mRNA |
Glutamine transporter SNAT1; GluOC induces SLC38A1 (and SLC7A11) to suppress ferroptosis | Upregulation inhibits ferroptosis and promotes survival of TNBC cells | Breast Cancer |
PubMed
Reference PMID: 40075587 |
|
NEDD4L
mRNA |
E3 ubiquitin ligase that promotes GPX4 ubiquitination and degradation, thereby enabling ferroptosis. | In TNBC cells, resveratrol induces ferroptosis via NEDD4L-mediated GPX4 degradation, increasing lipid peroxidation and cell death. | Breast Cancer |
PubMed
Reference PMID: 40316059 |
|
HIF1A
mRNA |
Inhibition of the SUCNR1/PI3K/HIF?1? pathway lowers SLC7A11 and promotes ferroptosis. | Blocking HIF?1? signaling induces ferroptosis and suppresses TNBC proliferation/migration in vitro and in vivo. | Breast Cancer |
PubMed
Reference PMID: 40532859 |
|
DHODH
mRNA |
Mitochondrial CoQH2 oxidoreductase that suppresses lipid peroxidation; USP24 deubiquitinates & stabilizes DHODH to block ferroptosis. | Stabilized DHODH limits ferroptosis and supports TNBC growth; targeting USP24�DHODH restores ferroptotic sensitivity. | Breast Cancer |
PubMed
Reference PMID: 40715045 |
|
USP24
mRNA |
Deubiquitinase USP24 stabilizes DHODH protein in mitochondria, suppressing lipid peroxidation and ferroptosis in TNBC cells. | Confers resistance to ferroptosis; targeting USP24 sensitizes TNBC cells to ferroptosis and impairs growth/migration. | Breast Cancer |
PubMed
Reference PMID: 40715045 |
|
ALOX15B
mRNA |
15?lipoxygenase?2 that produces lipid hydroperoxides; IRF1?ALOX15B axis enhances ferroptosis. | Overexpression/activation increases erastin?induced ferroptosis and suppresses TNBC progression in models. | Breast Cancer |
PubMed
Reference PMID: 40749811 |
|
IRF1
mRNA |
IFN-?/IRF1 transcriptionally activates ALOX15B, increases lipid peroxidation and sensitizes TNBC cells to ferroptosis (e.g., with erastin/RSL3). | Promotes ferroptosis; suppresses TNBC growth and enhances responsiveness to IFN-?�based or ferroptosis-inducing therapies. | Breast Cancer |
PubMed
Reference PMID: 40749811 |