Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
miR-29a-3p
miRNA |
Not reported | low miR-29a-3p correlates with poor TNBC prognosis and immune evasion | Breast Cancer |
PubMed
Reference PMID: 35116358 |
|
miR-29b-3p
miRNA |
Not reported | Tumor suppressor: inhibits BC cell proliferation, migration and invasion (targets SPARC/COL4A2) | Breast Cancer |
PubMed
Reference PMID: 36140539 |
|
miR-30a-5p
miRNA |
Not reported | Tumor suppressor: inhibits BC cell proliferation (targets UBE3C, CyclinB1/D1, c-Myc) | Breast Cancer |
PubMed
Reference PMID: 22476851 |
|
miR-30b-5p
miRNA |
Not reported | Oncogenic (especially in TNBC): promotes proliferation, migration, invasion by targeting ASPP2 and activating AKT | Breast Cancer |
PubMed
Reference PMID: 32420372 |
|
miR-31-5p
miRNA |
Not reported | Tumor suppressor (anti-metastatic): restoration of miR-31-5p inhibits TNBC cell migration and invasion | Breast Cancer |
PubMed
Reference PMID: 29796229 |
|
miR-33a-5p
miRNA |
Not reported | Tumor suppressor in TNBC: inhibits proliferation and metastasis by targeting EZH2 | Breast Cancer |
PubMed
Reference PMID: 32206036 |
|
miR-374b-5p
miRNA |
Not reported | Tumor suppressor in TNBC: higher miR-374b-5p levels predict better survival; restoration suppresses cell invasion and proliferation | Breast Cancer |
PubMed
Reference PMID: 26062749 |
|
miR-374c-5p
miRNA |
Not reported | Tumor suppressor: downregulated in BC; overexpression inhibits proliferation, migration and EMT, and induces apoptosis (via TAF7/DEPDC1) | Breast Cancer |
PubMed
Reference PMID: 31162714 |
|
TFRC
mRNA |
Transferrin receptor?1 imports iron and increases labile Fe2+, sensitizing to ferroptosis. | ER?negative/TNBC cells with higher TFRC show greater sensitivity to sulfasalazine?induced ferroptosis. | Breast Cancer |
PubMed
Reference PMID: 31173262 |
|
IFNG
mRNA |
IFN??/JAK?STAT�IRF1 axis transcriptionally activates ALOX15B, enhancing lipid peroxidation and ferroptosis sensitivity in TNBC cells. | Sensitizes TNBC cells to ferroptosis; tumor?suppressive. | Breast Cancer |
PubMed
Reference PMID: 33495298 |