Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
NOD2
mRNA |
NOD2 drives innate immune signaling and autophagy in cancer | Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role. | Breast Cancer |
PubMed
Reference PMID: 32144252 |
|
LEP
mRNA |
Leptin promotes autophagy in breast cancer microenvironment | Leptin inducesautophagy to promote proliferation, migration, morphological changes, and ERK phosphorylation in triple-negative (MDA-MB-231) breast cancer cells. | Breast Cancer |
PubMed
Reference PMID: 33763424 |
|
SESN2
mRNA |
Stress-inducible mTORC1 brake; SESN2 knockdown diminishes autophagy (?LC3-II, ?p62) in TNBC cells under betulinic acid treatment. | Cytoprotective autophagy: SESN2 loss sensitizes MDA-MB-231 and HS578T TNBC cells to betulinic acid. | Breast Cancer |
PubMed
Reference PMID: 36611970 |
|
VDAC1
mRNA |
DYNLT1 stabilizes the voltage-dependent anion channel 1 (VDAC1) by hindering E3 ligase Parkin-mediated VDAC1 ubiquitination and degradation. | The protein DYNLT1 stabilizes VDAC1 by preventing Parkin-mediated degradation, enhancing mitochondrial metabolism and fueling tumor proliferation, especially in TNBC subtypes. | Breast Cancer |
PubMed
Reference PMID: 37280526 |
|
OPTN
mRNA |
Selective autophagy receptor (cargo adaptor); regulates degradation pathways and intersects with TGF-? signaling. | OPTN limits metastasis in TNBC; loss of OPTN enhances metastatic behavior in cell and mouse models. | Breast Cancer |
PubMed
Reference PMID: 36823950 |
|
DNM1L
mRNA |
Mitochondrial fission GTPase; promotes mitophagy by enabling segregation of damaged mitochondria. | ELK3�DRP1 axis determines chemosensitivity of TNBC; DRP1 activity linked to drug response. | Breast Cancer |
PubMed
Reference PMID: 37422450 |
|
ATG13
mRNA |
Core ULK1-complex subunit initiating autophagosome formation; release of miR-224-5p suppression increases ATG13/ULK1 axis activity. | Exosomal circEGFR promotes ATG13/ULK1-driven autophagy to enhance malignant progression and metastasis in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 38280941 |
|
STUB1
mRNA |
METTL3-mediated m6A modification increases STUB1 (CHIP), which inhibits autophagy in TNBC cells. | Inhibition of autophagy via elevated STUB1 contributes to anti-tumor effects; modulation of STUB1 reduces TNBC cell growth. | Breast Cancer |
PubMed
Reference PMID: 38823344 |
|
TFEB
mRNA |
Master transcription factor driving autophagy�lysosome gene program; activated/nuclear TFEB elevates autophagic flux. | TRIM25-mediated neddylation activates TFEB, inducing cytoprotective autophagy that desensitizes TNBC cells to paclitaxel. | Breast Cancer |
PubMed
Reference PMID: 38926803 |
|
TSG101
mRNA |
ESCRT-I component required for autophagosome maturation/closure and cargo sorting (context-dependent). | Mammary tumors induced by Tsg101 loss display triple?negative phenotype; implicates TSG101 in TNBC biology. | Breast Cancer |
PubMed
Reference PMID: 40624726 |