Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
BCL2
mRNA |
BCL-2 binds BECN1 to inhibit autophagy; BCL-2 inhibition can derepress autophagy. | BCL2 suppresses autophagy in MCF7 breast cancer cells by binding to Beclin-1, and this suppression enhances tumor cell growth. | Breast Cancer |
PubMed
Reference PMID: 20885445 |
|
HSPA8
mRNA |
HSPA8 was mainly involved in partner-mediated autophagy | In (TNBC), HSPA8 is overexpressed and emerges as a key biomarker linked to poor prognosis, immune infiltration, and clinicopathological features. | Breast Cancer |
PubMed
Reference PMID: 36452344 |
|
LEPR
mRNA |
Autophagy activation and SREBP-1 induction, leading to stimulated cell proliferation | Elicits metabolic reprogramming in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 33799880 |
|
PINK1
mRNA |
Kinase that initiates PRKN-dependent mitophagy on damaged mitochondria. | PINK1/PRKN mitophagy supports TNBC cell survival and chemoresistance; inhibiting this axis sensitizes cells to therapy. | Breast Cancer |
PubMed
Reference PMID: 33929971 |
|
STING1
mRNA |
cGAS�STING signaling supports TNBC growth; pathway inhibition triggers autophagy-dependent cell death, implicating autophagy in STING-driven survival. | Pro-survival pathway in TNBC; blocking STING induces autophagy-dependent death in TNBC models. | Breast Cancer |
PubMed
Reference PMID: 35992877 |
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | Breast Cancer |
PubMed
Reference PMID: 35467897 |
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | Breast Cancer |
PubMed
Reference PMID: 28017659 |
|
HK2
mRNA |
HK2 is targeted by miR-216b, leading to inhibition of the mTOR pathway, which in turn stimulates autophagy | miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC | Breast Cancer |
PubMed
Reference PMID: 34345220 |
|
TOLLIP
mRNA |
Autophagy receptor mediating selective autophagic degradation of TMEM63A/DERL1 axis. | TOLLIP-mediated autophagic degradation pathway drives TNBC progression; disrupting VCP/TMEM63A/DERL1 reduces oncogenic effects in vitro and in vivo. | Breast Cancer |
PubMed
Reference PMID: 35920704 |
|
NOD2
mRNA |
NOD2 drives innate immune signaling and autophagy in cancer | Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role. | Breast Cancer |
PubMed
Reference PMID: 29615116 |