Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
BECN1
mRNA |
Core autophagy regulator; forms complexes with class III PI3K to initiate autophagosome formation. | Beclin1 regulates autophagy-mediated survival in TNBC; loss or suppression sensitizes to chemotherapy. | Breast Cancer |
PubMed
Reference PMID: 22733132 |
|
MTOR
mRNA |
AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis | The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition | Breast Cancer |
PubMed
Reference PMID: 27526942 |
|
USP10
mRNA |
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy. | USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1. | Breast Cancer |
PubMed
Reference PMID: 21962518 |
|
USP10
mRNA |
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy. | USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1. | Breast Cancer |
PubMed
Reference PMID: 36248971 |
|
ELAPOR1 (EVA1A)
mRNA |
EVA1A positively regulates autophagy/mitophagy; flubendazole targets EVA1A to trigger excessive autophagy/mitophagy. | Anti-tumor via autophagy: EVA1A-driven (flubendazole-induced) autophagy/mitophagy suppresses TNBC proliferation and migration. | Breast Cancer |
PubMed
Reference PMID: 32724459 |
|
TMEM41B
mRNA |
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis. | Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B | Breast Cancer |
PubMed
Reference PMID: 39709500 |
|
TMEM41B
mRNA |
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis. | Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B | Breast Cancer |
PubMed
Reference PMID: 36931971 |
|
ATG2B
mRNA |
In TNBC cancer stem cells (CSCs), autophagy is suppressed via upregulation of miR-181a, which directly targets ATG5 and ATG2B, reducing their expression and dampening autophagy | Same study shows miR?181a suppresses ATG2B to inhibit autophagy and TNBC stemness/tumorigenicity. | Breast Cancer |
PubMed
Reference PMID: 35029026 |
|
CASP3
mRNA |
Promote cytoprotective autophagy under non-lethal stresses like starvation or proteasome inhibition. | Caspase-3�mediated cleavage of autophagy proteins linked to TNBC apoptosis�autophagy balance and treatment responses. | Breast Cancer |
PubMed
Reference PMID: 39982959 |
|
SNAP29
mRNA |
SNARE protein that mediates autophagosome�lysosome fusion. | SNAP29 is essential for autophagic flux in TNBC; silencing impairs autophagy and suppresses tumor cell survival. | Breast Cancer |
PubMed
Reference PMID: 35256275 |