Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
TRIM27
mRNA |
E3 ligase TRIM27 ubiquitinates and destabilizes ULK1, inhibiting autophagy initiation. | Promotes primary tumor growth in breast cancer models; evidence includes 4T1 (TNBC) systems. | Breast Cancer |
PubMed
Reference PMID: 35670107 |
|
PIK3CA
mRNA |
Encodes p110? catalytic subunit of PI3K; regulates PI3K/AKT/mTOR signaling that suppresses autophagy. | PIK3CA mutations alter PI3K/AKT/mTOR signaling; inhibitors restore autophagy and sensitize TNBC to therapy. | Breast Cancer |
PubMed
Reference PMID: |
|
ATG7
mRNA |
Core autophagy E1-like enzyme that mediates LC3/ATG8 lipidation (autophagosome formation). | Higher ATG7 expression associates with better prognosis; ATG7 suppresses proliferation and migration and promotes apoptosis in TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 30988371 |
|
TP53
mRNA |
Loss of TP53 promotes autophagy and chemoresistance in TNBC | Mutant TP53 enhances survival of TNBC cells via autophagy | Breast Cancer |
PubMed
Reference PMID: 23650262 |
|
TBK1
mRNA |
Serine/threonine kinase that phosphorylates autophagy receptors such as OPTN and regulates selective autophagy. | TBK1 inhibition reduces autophagy and sensitizes TNBC cells to chemotherapy and targeted therapy (MDA-MB-231, xenografts). | Breast Cancer |
PubMed
Reference PMID: 24449872 |
|
TBK1
mRNA |
Serine/threonine kinase that phosphorylates autophagy receptors such as OPTN and regulates selective autophagy. | TBK1 inhibition reduces autophagy and sensitizes TNBC cells to chemotherapy and targeted therapy (MDA-MB-231, xenografts). | Breast Cancer |
PubMed
Reference PMID: 33454423 |
|
MAPK3
mRNA |
K48-linked ubiquitination and proteasomal degradation of ULK1 | MAPK3 (ERK1) signaling directly to autophagy regulation (specifically mitophagy via ULK1) and demonstrates its impact on breast cancer progression. | Breast Cancer |
PubMed
Reference PMID: 33213267 |
|
BNIP3L
mRNA |
Mitophagy receptor (NIX); mediates BNIP3L/NIX-dependent mitophagy. | Exosomal ITGB4 from TNBC cells induces BNIP3L/NIX-dependent mitophagy in CAFs, promoting proliferation/EMT/invasion and tumor growth in co-transplantation models. | Breast Cancer |
PubMed
Reference PMID: 31534187 |
|
GABARAP
mRNA |
Member of Atg8 family; regulates autophagosome maturation and cargo recruitment. | Upregulation of GABARAP enhances autophagy and promotes TNBC progression. Silencing reduces migration and invasion in vitro. | Breast Cancer |
PubMed
Reference PMID: 33591943 |
|
STK11
mRNA |
LKB1 regulates AMPK-mTOR-autophagy signaling in breast cancer | Loss of STK11 promotes tumor growth through impaired autophagy in TNBC | Breast Cancer |
PubMed
Reference PMID: 28696138 |