Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-21-5p
miRNA |
Knockdown increases autophagy via inhibition of PI3K/AKT/mTOR (?Beclin-1, ?LC3-II), enhancing endocrine-therapy-induced autophagic cell death. | Sensitizes ER+ breast cancer cells to tamoxifen/fulvestrant; promotes autophagy when inhibited. | Breast Cancer |
PubMed
Reference PMID: 26796263 |
|
hsa-miR-20b-5p
miRNA |
Suppresses autophagy by targeting RB1CC1/FIP200, reducing LC3-II (shown in MDA-MB-231). | Autophagy inhibition supports proliferation/survival in the TNBC cell line MDA?MB?231. | Breast Cancer |
PubMed
Reference PMID: 26829385 |
|
hsa-miR-96-5p
miRNA |
Inhibits autophagy by directly targeting FOXO1; reduces LC3-II and increases p62 in MDA-MB-231 under starvation | Pro-tumorigenic: enhances proliferation, migration, and invasion; suppresses apoptosis in MDA-MB-231 | Breast Cancer |
PubMed
Reference PMID: 28588711 |
|
hsa-miR-20a-5p
miRNA |
Inhibits the basal and nutrient starvation-induced autophagic flux and lysosomal proteolytic activity | miR-20a promotes tumor initiation and tumor growth. | Breast Cancer |
PubMed
Reference PMID: 28628113 |
|
hsa-miR-23a-3p
miRNA |
Promotes autophagy and inhibits apoptosis via XIAP/Autophagy pathway in breast cancer cells. | Pro-survival autophagy; may contribute to therapy resistance. | Breast Cancer |
PubMed
Reference PMID: 28671686 |
|
hsa-miR-495-3p
miRNA |
miR-495-3p mimics downregulate GRP78 and reduce p?AKT/mTOR signaling (autophagy-related pathway) in a TNBC drug-resistance model. | Sensitizes TNBC cells to pirarubicin and reverses drug resistance. | Breast Cancer |
PubMed
Reference PMID: 34935899 |
|
hsa-miR-181a-5p
miRNA |
Suppresses autophagy via direct repression of ATG5 and/or ATG2B. | Reduces autophagy, increasing cancer stemness and aggressive features in TNBC. | Breast Cancer |
PubMed
Reference PMID: 35029026 |
|
hsa-miR-30a-5p
miRNA |
miR-30a-3p negatively regulated autophagy by autophagy related 12 (Atg12) | Altered mammary structure in the involution of the mammary glands of mice, which was indicative of alteration in mammary remodeling | Breast Cancer |
PubMed
Reference PMID: 37762652 |
|
hsa-miR-4295
miRNA |
Targets ITPR1 to suppress autophagy; RMST lncRNA sponges miR-4295, restoring ITPR1 and increasing autophagic flux (?LC3-II/I, ?p62). | miR-4295 promotes proliferation/migration; RMST/ITPR1 counteracts this and suppresses TNBC progression via pro-autophagic signaling. | Breast Cancer |
PubMed
Reference PMID: 40287640 |
|
hsa-miR-27a-3p
miRNA |
Promotes autophagy by targeting/relieving BNIP3; CAF exosomal circFOXO1 lowers miR-27a-3p, increasing BNIP3 and autophagy during radiotherapy. | Increases radioresistance and pro?tumor traits in TNBC (MDA?MB?231); autophagy inhibition (3?MA) weakens these effects. | Breast Cancer |
PubMed
Reference PMID: 40784956 |