Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
PIK3C3
mRNA |
Class III PI3K (VPS34) generates PI3P to initiate autophagosome formation; pharmacologic inhibition blocks autophagy. | In TNBC cell lines, VPS34 inhibition with SAR405 altered immunogenic signaling and activated NF-?B/CXCL10; highlights autophagy�s role in TNBC response. | Breast Cancer |
PubMed
Reference PMID: 40691137 |
|
miR-16-5p
miRNA |
Enhances autophagy through ZBTB16/G6PD axis | Increases antitumor efficacy in HER2-positive BC | Breast Cancer |
PubMed
Reference PMID: 38110365 |
|
circCDYL
miRNA |
Promotes autophagy via miR-1275-ATG7/ULK1 axis | Enhances breast cancer progression | Breast Cancer |
PubMed
Reference PMID: 32213200 |
|
circEGFR
miRNA |
Facilitates autophagy through miR-224-5p/ATG13/ULK1 loop | Promotes TNBC progression and metastasis | Breast Cancer |
PubMed
Reference PMID: 38280941 |
|
miR-224-5p
miRNA |
Inhibits autophagy by targeting Smad4 | Facilitates metastasis | Breast Cancer |
PubMed
Reference PMID: 30389135 |
|
miR-3653
miRNA |
Blocks autophagy via ATG12 and AMBRA1 | Inhibits EMT and metastasis | Breast Cancer |
PubMed
Reference PMID: 37464439 |
|
miR-25
miRNA |
Upregulate ULK1 | Induce autophagy | Breast Cancer |
PubMed
Reference PMID: 25026296 |
|
miR-200c
miRNA |
Reduces expression levels of LC3 and UBQLN1 | Breast Cancer |
PubMed
Reference PMID: 25044403 |
|
|
miR-27a
miRNA |
miR-27a suppressed LC3-II and p62 expressions to inhibit autophagy | and sensitized cancer cells to doxorubicin and paclitaxel | Breast Cancer |
PubMed
Reference PMID: 32066826 |
|
miR-129-5p
miRNA |
miR-129-5p suppressed HMGB1 to inhibit autophagy | sensitized breast cancer cells to taxol treatment | Breast Cancer |
PubMed
Reference PMID: 31664305 |