Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-340-5p
miRNA |
Targets LGR5 (Wnt/β-catenin pathway) | Tumor suppressor; inhibits proliferation and drug resistance | Breast Cancer |
PubMed
Reference PMID: 30300682 |
|
hsa-miR-383-5p
miRNA |
Targets PD-L1 (immune checkpoint) | Tumor suppressor; inhibits proliferation/migration and induces apoptosis | Breast Cancer |
PubMed
Reference PMID: 33359245 |
|
hsa-miR-448
miRNA |
Hsa-miR-448 suppresses KDM5B expression in TNBC, which downregulates MALAT-mediated oncogenic functions | Tumor suppressor; inhibits growth and sensitizes to chemotherapy | Breast Cancer |
PubMed
Reference PMID: 40318146 |
|
hsa-miR-96-5p
miRNA |
Targets FOXO1, PTEN and others (PI3K/AKT) and inhibits apoptosis | Oncogenic; promotes proliferation, invasion and chemoresistance | Breast Cancer |
PubMed
Reference PMID: 28588711 |
|
ZC3H12A
mRNA |
RNase MCPIP1; degrades mRNAs of survival genes and can promote pro-apoptotic gene expression. | Acts as tumor suppressor in BC; overexpression triggers apoptosis in some TNBC cells. | Breast Cancer |
PubMed
Reference PMID: 26833120 |
|
CCAR1
mRNA |
Coactivator that augments p53-dependent transcription and is required for chemo-induced apoptosis. | Activation induces apoptosis in TNBC cells via p38/JNK signaling. | Breast Cancer |
PubMed
Reference PMID: 27687593 |
|
TRIAP1
mRNA |
TP53-regulated inhibitor of apoptosis 1; inhibits apoptosome formation and caspase-9 activation. | Upregulated in drug-resistant breast cancer cells, contributing to chemo resistance. | Breast Cancer |
PubMed
Reference PMID: 25998939 |
|
HTR2A
mRNA |
5-HT2A receptor; antagonism can induce apoptosis in breast cancer cells. | HTR2A antagonists induce apoptosis in BC cell lines. | Breast Cancer |
PubMed
Reference PMID: 26768715 |
|
FADD
mRNA |
Adaptor protein that bridges activated death receptors to procaspase-8 at the DISC, promoting extrinsic apoptosis. | Required for TNF?/TRAIL-induced extrinsic apoptosis in TNBC cells; modulates sensitivity to death ligands. | Breast Cancer |
PubMed
Reference PMID: 26733177 |
|
DICER1
mRNA |
Processes miRNAs; loss alters apoptotic miRNA expression leading to reduced apoptosis. | Lower Dicer expression in TNBC than ER+ breast cancers, implying reduced miRNA-mediated apoptotic control. | Breast Cancer |
PubMed
Reference PMID: 27260947 |