Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
hsa-miR-130a-3p
miRNA |
Targets SATB1 (regulating chromatin/EMT) | Tumor suppressor; suppresses proliferation and promotes apoptosis (H19 knockdown increases miR-130a-3p) | Breast Cancer |
PubMed
Reference PMID: 33324070 |
|
hsa-miR-130a-5p
miRNA |
Predicted targets include PTEN/JAK-STAT pathway; downregulated in BC | Tumor suppressor; downregulation observed in BC suggests it normally inhibits growth | Breast Cancer |
PubMed
Reference PMID: 32972352 |
|
hsa-miR-130b-3p
miRNA |
overexpression often inhibits apoptosis | ESR1/miR-130b-3p/HOTAIR may be promising targets for clinical treatment of endocrine therapy-resistant breast cancer | Breast Cancer |
PubMed
Reference PMID: 30142342 |
|
hsa-miR-127
miRNA |
hsa-miR-127 can promote cell proliferation and migration while inhibiting apoptosis in certain cancer cells, like glioma cells. | In triple-negative BC, miR-127 overexpression increases stem cell sensitivity to radiotherapy drugs | Breast Cancer |
PubMed
Reference PMID: 36371182 |
|
hsa-miR-138-5p
miRNA |
Targets PD-L1 and MMP2/9 (affecting PI3K/AKT) and induces apoptosis | Tumor suppressor; inhibits proliferation and motility, induces apoptosis | Breast Cancer |
PubMed
Reference PMID: 33545160 |
|
hsa-miR-139-3p
miRNA |
RAB1A knockdown can suppress proliferation and induce apoptosis in certain cancer cells | tumor suppressive role in breast cancer by targeting RAB1A | Breast Cancer |
PubMed
Reference PMID: 31485677 |
|
hsa-miR-139-5p
miRNA |
Induces apoptosis and acts as a tumor suppressor by regulating caspase-dependent pathways.Regulates TGF-β, MAPK and PI3K pathways in metastasis | Overexpression of miR-139-5p results in suppression in MDA-MB-231 breast cancer cell line | Breast Cancer |
PubMed
Reference PMID: 24158791 |
|
hsa-miR-146a-5p
miRNA |
Targets SOX5 (and TR6/IRAK1) to inhibit NF-κB/PI3K signaling | hsa-miR-146a-5p was downregulated in BC is a tumor suppressor miRNA | Breast Cancer |
PubMed
Reference PMID: 38250762 |
|
hsa-miR-191-5p
miRNA |
Targets SOX4 (and p53 loop regulators) to repress apoptosis | Oncogenic; inhibits apoptosis and promotes proliferation/chemoresistance | Breast Cancer |
PubMed
Reference PMID: 28450532 |
|
hsa-miR-199a-3p
miRNA |
miR-199a can induce apoptosis either by up-regulating the level of pro-apoptotic protein or decreasing the expression of anti-apoptotic protein | Inhibits cell proliferation and cycle progression/Reduces the risk of breast cancer | Breast Cancer |
PubMed
Reference PMID: 26399456 |