Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
AIFM2
mRNA |
AIFM2 (FSP1) is a mitochondrial oxidoreductase that can induce caspase-independent apoptosis and also functions in ferroptosis suppression via CoQ regeneration; implicated in oncogenic ceRNA axes affecting cell survival. | AIFM2 upregulation linked to tumor progression in breast cancer (reported in HER2+ contexts). | Breast Cancer |
PubMed
Reference PMID: 34668628 |
|
PLSCR1
mRNA |
Phospholipid scramblase 1; nuclear PLSCR1 modulates STAT signaling and survival pathways. | potentially involved in T cell signaling under regulation of B7 family proteins, a be a potential target for breast cancer immunotherapy. | Breast Cancer |
PubMed
Reference PMID: 27622076 |
|
DFFA
mRNA |
ICAD (DFFA) is cleaved by caspase-3 to release DFFB/CAD, enabling DNA fragmentation during apoptosis. | Thymoquinone treatment upregulated DFFA mRNA in MDA-MB-231 and MDA-MB-468 cells, correlating with apoptosis induction. | Breast Cancer |
PubMed
Reference PMID: 35631261 |
|
GPER1
mRNA |
G-protein coupled estrogen receptor; loss/activation can trigger JNK/p53/Noxa-mediated mitochondrial apoptosis. | High GPER1 correlates with poor prognosis in TNBC; modulation affects apoptosis. | Breast Cancer |
PubMed
Reference PMID: 36042244 |
|
CSNK2A1
mRNA |
Casein kinase II alpha (CK2?) phosphorylates targets to promote survival signaling and suppress apoptosis. | Overexpressed in breast cancer (including TNBC); CK2 inhibition induces apoptosis. | Breast Cancer |
PubMed
Reference PMID: 36114992 |
|
CASP9
mRNA |
Initiator caspase of the intrinsic (mitochondrial) apoptosis pathway activated by Apaf-1 in the apoptosome; activates executioner caspases like caspase-3. | CASP9 expression associates with prognosis in breast cancer; restoration of caspase-9 can suppress metastatic behavior in TNBC models in recent studies. | Breast Cancer |
PubMed
Reference PMID: 36199443 |
|
PDCD10
mRNA |
Scaffolding component (CCM3); can promote apoptosis through stress kinases in some contexts. | Loss increases chemoresistance in breast cancer, suggesting a role in apoptosis and therapy response. | Breast Cancer |
PubMed
Reference PMID: 30408026 |
|
BCL2L14
mRNA |
BCL2L14 (BCL-G) is a BCL-2 family member with pro-apoptotic BH3-like activity in certain contexts, promoting mitochondrial apoptosis when active. | BCL2L14 fusions/alterations have been observed in aggressive breast cancers; linked to therapy resistance features. | Breast Cancer |
PubMed
Reference PMID: 32321829 |
|
CASP2
mRNA |
Caspase-2 acts as a stress-response initiator caspase involved in DNA damage-induced apoptosis and can function upstream of mitochondrial pathways. | Altered CASP2 expression associates with prognosis in breast cancer/TNBC; functional context varies by study. | Breast Cancer |
PubMed
Reference PMID: 37093683 |
|
CCAR2
mRNA |
Inhibits SIRT1 to stabilize p53 and promote p53-mediated apoptosis; also coactivates ER?/PEA3 under some contexts. | Dual role in breast cancer; linked to prognosis and can modulate apoptosis in BC. | Breast Cancer |
PubMed
Reference PMID: 37524873 |