Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
AKT1
mRNA |
AKT1 (PKB?) is a serine/threonine kinase that promotes cell survival by phosphorylating/inactivating pro-apoptotic factors (BAD, FOXO), inhibiting caspase activation and promoting MDM2-mediated p53 degradation; isoform-specific effects exist in breast cancer. | AKT1 activation impairs apoptosis and promotes tumor initiation in breast cancer; isoform-specific roles affect therapy response in TNBC. | Breast Cancer |
PubMed
Reference PMID: 31752925 |
|
CASP3
mRNA |
Executioner caspase that cleaves multiple substrates to execute apoptosis following activation by initiator caspases. | Cleaved (active) caspase-3 in TNBC correlates with chemotherapy response and can be a marker of apoptosis. | Breast Cancer |
PubMed
Reference PMID: 31949833 |
|
TP53
mRNA |
TP53 encodes p53, a transcription factor that activates pro-apoptotic genes (BAX, PUMA/BBC3, NOXA) in response to DNA damage and stress, inducing mitochondrial apoptosis and cell-cycle arrest. | TP53 is frequently mutated in breast cancer, especially TNBC; mutant p53 alters apoptosis and is associated with therapy response and prognosis. | Breast Cancer |
PubMed
Reference PMID: 32061310 |
|
DLC1
mRNA |
Tumor-suppressor RhoGAP activity; restoration of DLC1 expression reduces pro-survival signaling and promotes apoptosis. | Curcumin restored DLC1 expression and promoted apoptosis in TNBC cell lines and xenografts. | Breast Cancer |
PubMed
Reference PMID: 32725802 |
|
BIRC2
mRNA |
Encodes cIAP1 which ubiquitinates caspases and inhibits apoptosis. | Overexpressed in TNBC and promotes chemoresistance. | Breast Cancer |
PubMed
Reference PMID: 33673050 |
|
BIRC3
mRNA |
Encodes cIAP2; inhibits caspases and activates NF-?B pro-survival signaling. | Overexpressed in TNBC contributing to apoptosis resistance. | Breast Cancer |
PubMed
Reference PMID: 33673050 |
|
TRPC5
mRNA |
Calcium channel; increased Ca2+ influx activates survival pathways and drug-resistance mechanisms. | promotes drug resistance in breast carcinoma via CaMKK?/AMPK?/mTOR pathway | Breast Cancer |
PubMed
Reference PMID: 33426511 |
|
RIPK1
mRNA |
Mediates death-receptor signaling; can trigger caspase-8-dependent apoptosis or necroptosis depending on context. | Restoring RIPK1 can trigger apoptosis in TNBC models and suppress progression. | Breast Cancer |
PubMed
Reference PMID: 33980862 |
|
XIAP
mRNA |
X-linked inhibitor of apoptosis protein (XIAP) binds and inhibits active caspases-3, -7, and -9, blocking apoptosis; also has E3 ligase activity that promotes survival signaling. | Higher XIAP expression in invasive breast cancer is associated with shorter survival and chemotherapy resistance. | Breast Cancer |
PubMed
Reference PMID: 34199946 |
|
DFFB
mRNA |
Caspase-activated DNase (CAD/DFF40) executes internucleosomal DNA fragmentation and chromatin condensation downstream of caspase-3. | DFF40-iRGD chimeric protein induces apoptosis and cytotoxicity in TNBC cells and reduces tumor growth in models. | Breast Cancer |
PubMed
Reference PMID: 34482510 |