Explore this research category across breast cancer datasets
| RNA Name | Mechanism of Action | Effect on Cancer | Cancer Type | Reference |
|---|---|---|---|---|
|
PAK2
mRNA |
PAK2 phosphorylates caspase-7 (Ser-30/Thr-173/Ser-239) and blocks caspase-7 activation, thereby inhibiting executioner caspase activity (anti-apoptotic effect). | PAK2 upregulation correlates with poorer outcomes and chemoresistance in breast cancer/TNBC and contributes to suppression of apoptosis. | Breast Cancer |
PubMed
Reference PMID: 39803692 |
|
FAP
mRNA |
Fibroblast activation protein alpha (FAP) expressed in tumor stroma promotes tumor-supportive signaling (PI3K/AKT) and can protect tumor cells from apoptosis; FAP targeting disrupts stromal support and increases tumor cell death. | FAP knockdown reduces tumor growth and increases apoptosis in breast cancer models. | Breast Cancer |
PubMed
Reference PMID: 24885257 |
|
CASP8
mRNA |
Initiator caspase in the extrinsic apoptosis pathway; activated at death-inducing signaling complex (DISC) and activates downstream executioner caspases. | Caspase-8 activation mediates extrinsic apoptosis in TNBC models under ER stress and DR5 activation. | Breast Cancer |
PubMed
Reference PMID: 29374147 |
|
TP53BP2
mRNA |
ASPP2 (TP53BP2) stimulates p53-mediated transactivation of pro-apoptotic genes; loss reduces p53-driven apoptosis. | Silencing of ASPP2 promotes proliferation and migration and reduces apoptosis in TNBC cells via PI3K/AKT pathway. | Breast Cancer |
PubMed
Reference PMID: 29568874 |
|
TNFRSF1A
mRNA |
TNF receptor 1 mediates TNF? signaling leading to either NF-?B-driven survival or assembly of death-inducing complexes that activate caspase-8 and extrinsic apoptosis. | TNFRSF1A expression links to NF-?B activation in breast cancer and can modulate apoptosis vs survival depending on context. | Breast Cancer |
PubMed
Reference PMID: 29621649 |
|
BCL2
mRNA |
Anti-apoptotic Bcl-2 family protein that sequesters pro-apoptotic BH3-only proteins and prevents mitochondrial outer membrane permeabilization (MOMP). | Bcl-2 inhibition sensitizes TNBC cells to chemotherapy; Bcl-2 expression patterns are subtype-dependent in breast cancer. | Breast Cancer |
PubMed
Reference PMID: 29876007 |
|
CASP7
mRNA |
Executioner caspase activated downstream of initiator caspases; executes apoptosis by cleaving cellular substrates. | Low cleaved caspase-7 levels associate with unfavorable outcome across breast cancers; caspase-7 activity impacts response to therapy. | Breast Cancer |
PubMed
Reference PMID: 30069746 |
|
SIRT2
mRNA |
NAD+-dependent deacetylase; modulates apoptosis via deacetylation of targets and ROS responses. | Often amplified/overexpressed in TNBC and promotes survival; SIRT2 loss sensitizes cells to ROS-induced apoptosis. | Breast Cancer |
PubMed
Reference PMID: 27503926 |
|
HRK
mRNA |
BH3-only pro-apoptotic Bcl-2 family member; binds Bcl-2/Bcl-xL to release Bax/Bak and promote mitochondrial apoptosis. | Breast Cancer |
PubMed
Reference PMID: 30774992 |
|
|
AIFM3
mRNA |
Mitochondrial oxidoreductase similar to AIF; upon release can mediate caspase-independent apoptosis via chromatin condensation and DNA fragmentation. | Overexpression in breast cancer linked to metastasis and poor prognosis. | Breast Cancer |
PubMed
Reference PMID: 31088422 |