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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

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388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
miR-125a-5p
miRNA 		inhibits proliferation and induces apoptosis miR?125a?5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer PMID: 34549308

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: miR-125a-5p

Mechanism of Action: inhibits proliferation and induces apoptosis

Effect on Cancer: miR?125a?5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer

PMID: 34549308
hsa-miR-125b-5p
miRNA 		Targets KIAA1522 (oncogenic protein) Tumor suppressor; inhibits proliferation and metastasis PMID: 30177391

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-125b-5p

Mechanism of Action: Targets KIAA1522 (oncogenic protein)

Effect on Cancer: Tumor suppressor; inhibits proliferation and metastasis

PMID: 30177391
hsa-miR-1297
miRNA 		Targets FA2H (fatty acid 2-hydroxylase) Oncogene; promotes proliferation, EMT and survival (knockdown increases apoptosis) PMID: 33014155

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-1297

Mechanism of Action: Targets FA2H (fatty acid 2-hydroxylase)

Effect on Cancer: Oncogene; promotes proliferation, EMT and survival (knockdown increases apoptosis)

PMID: 33014155
hsa-miR-130a-3p
miRNA 		Targets SATB1 (regulating chromatin/EMT) Tumor suppressor; suppresses proliferation and promotes apoptosis (H19 knockdown increases miR-130a-3p) PMID: 33324070

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-130a-3p

Mechanism of Action: Targets SATB1 (regulating chromatin/EMT)

Effect on Cancer: Tumor suppressor; suppresses proliferation and promotes apoptosis (H19 knockdown increases miR-130a-3p)

PMID: 33324070
hsa-miR-130a-5p
miRNA 		Predicted targets include PTEN/JAK-STAT pathway; downregulated in BC Tumor suppressor; downregulation observed in BC suggests it normally inhibits growth PMID: 32972352

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-130a-5p

Mechanism of Action: Predicted targets include PTEN/JAK-STAT pathway; downregulated in BC

Effect on Cancer: Tumor suppressor; downregulation observed in BC suggests it normally inhibits growth

PMID: 32972352
hsa-miR-130b-3p
miRNA 		overexpression often inhibits apoptosis ESR1/miR-130b-3p/HOTAIR may be promising targets for clinical treatment of endocrine therapy-resistant breast cancer PMID: 30142342

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-130b-3p

Mechanism of Action: overexpression often inhibits apoptosis

Effect on Cancer: ESR1/miR-130b-3p/HOTAIR may be promising targets for clinical treatment of endocrine therapy-resistant breast cancer

PMID: 30142342
hsa-miR-127
miRNA 		hsa-miR-127 can promote cell proliferation and migration while inhibiting apoptosis in certain cancer cells, like glioma cells. In triple-negative BC, miR-127 overexpression increases stem cell sensitivity to radiotherapy drugs PMID: 36371182

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-127

Mechanism of Action: hsa-miR-127 can promote cell proliferation and migration while inhibiting apoptosis in certain cancer cells, like glioma cells.

Effect on Cancer: In triple-negative BC, miR-127 overexpression increases stem cell sensitivity to radiotherapy drugs

PMID: 36371182
hsa-miR-138-5p
miRNA 		Targets PD-L1 and MMP2/9 (affecting PI3K/AKT) and induces apoptosis Tumor suppressor; inhibits proliferation and motility, induces apoptosis PMID: 33545160

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-138-5p

Mechanism of Action: Targets PD-L1 and MMP2/9 (affecting PI3K/AKT) and induces apoptosis

Effect on Cancer: Tumor suppressor; inhibits proliferation and motility, induces apoptosis

PMID: 33545160
hsa-miR-139-3p
miRNA 		RAB1A knockdown can suppress proliferation and induce apoptosis in certain cancer cells tumor suppressive role in breast cancer by targeting RAB1A PMID: 31485677

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-139-3p

Mechanism of Action: RAB1A knockdown can suppress proliferation and induce apoptosis in certain cancer cells

Effect on Cancer: tumor suppressive role in breast cancer by targeting RAB1A

PMID: 31485677
hsa-miR-139-5p
miRNA 		Induces apoptosis and acts as a tumor suppressor by regulating caspase-dependent pathways.Regulates TGF-β, MAPK and PI3K pathways in metastasis Overexpression of miR-139-5p results in suppression in MDA-MB-231 breast cancer cell line PMID: 24158791

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-139-5p

Mechanism of Action: Induces apoptosis and acts as a tumor suppressor by regulating caspase-dependent pathways.Regulates TGF-β, MAPK and PI3K pathways in metastasis

Effect on Cancer: Overexpression of miR-139-5p results in suppression in MDA-MB-231 breast cancer cell line

PMID: 24158791