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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

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388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
USP2-AS1
lncRNA 		Part of a prognostic 2-lncRNA signature (BCCuS) impacting copper-induced cell death pathways Predicts breast cancer prognosis and immune dysfunction PMID: 36699089

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

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Cuproptosis
lncRNA
Breast Cancer
RNA Name: USP2-AS1

Mechanism of Action: Part of a prognostic 2-lncRNA signature (BCCuS) impacting copper-induced cell death pathways

Effect on Cancer: Predicts breast cancer prognosis and immune dysfunction

PMID: 36699089
NIFK-AS1
lncRNA 		Works in conjunction with USP2-AS1 in the BCCuS signature Predicts sensitivity to therapies and patient survival PMID: 36699089

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Cuproptosis
lncRNA
Breast Cancer
RNA Name: NIFK-AS1

Mechanism of Action: Works in conjunction with USP2-AS1 in the BCCuS signature

Effect on Cancer: Predicts sensitivity to therapies and patient survival

PMID: 36699089
C6orf99
lncRNA 		Regulates DLD mRNA via miR-370-3p and miR-432-5p in the cuproptosis pathway Associated with endocrine therapy resistance in ER+ BC PMID: 37143115

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Cuproptosis
lncRNA
Breast Cancer
RNA Name: C6orf99

Mechanism of Action: Regulates DLD mRNA via miR-370-3p and miR-432-5p in the cuproptosis pathway

Effect on Cancer: Associated with endocrine therapy resistance in ER+ BC

PMID: 37143115
CARMN
lncRNA 		Involved in the PRNP/miRNA hsa-miR-192-5p and hsa-miR-215-5p/lncRNA CARMN ceRNA network Regulates PRNP in cuproptosis in breast cancer PMID: 36980514

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Cuproptosis
lncRNA
Breast Cancer
RNA Name: CARMN

Mechanism of Action: Involved in the PRNP/miRNA hsa-miR-192-5p and hsa-miR-215-5p/lncRNA CARMN ceRNA network

Effect on Cancer: Regulates PRNP in cuproptosis in breast cancer

PMID: 36980514
LINC01863
lncRNA 		Impacts cell proliferation in BC, associated with drug sensitivity Role in immune infiltration and therapeutic responses PMID: 38772805

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Cuproptosis
lncRNA
Breast Cancer
RNA Name: LINC01863

Mechanism of Action: Impacts cell proliferation in BC, associated with drug sensitivity

Effect on Cancer: Role in immune infiltration and therapeutic responses

PMID: 38772805
AC104211.1
lncRNA 		Similar role as LINC01863, influencing BC cell viability and sensitivity to therapies Prognostic and therapeutic implications PMID: 38772805

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Cuproptosis
lncRNA
Breast Cancer
RNA Name: AC104211.1

Mechanism of Action: Similar role as LINC01863, influencing BC cell viability and sensitivity to therapies

Effect on Cancer: Prognostic and therapeutic implications

PMID: 38772805
MEG3
lncRNA 		Activates NLRP3/caspase-1/GSDMD pathway to induce pyroptosis Anti-tumor effect in triple-negative breast cancer (TNBC) by inducing pyroptosis PMID: 34326697

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Pyroptosis
lncRNA
Breast Cancer
RNA Name: MEG3

Mechanism of Action: Activates NLRP3/caspase-1/GSDMD pathway to induce pyroptosis

Effect on Cancer: Anti-tumor effect in triple-negative breast cancer (TNBC) by inducing pyroptosis

PMID: 34326697
Malat1
lncRNA 		Suppresses pyroptosis and T cell-mediated killing by inducing SERPINB6B Promotes tumor initiation, metastasis, and immune evasion PMID: 38195932

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Pyroptosis
lncRNA
Breast Cancer
RNA Name: Malat1

Mechanism of Action: Suppresses pyroptosis and T cell-mediated killing by inducing SERPINB6B

Effect on Cancer: Promotes tumor initiation, metastasis, and immune evasion

PMID: 38195932
8 pyroptosis-related lncRNAs 0.0, AC004585.1, DLGAP1-AS1, TNFRSF14-AS1, AL606834.2, Z68871.1, AC009119.1, LINC01871, AL136368.1
lncRNA 		Risk model assessing immune infiltration and tumor microenvironment interactions Prognostic and therapeutic potential in breast cancer PMID: 35702100

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Pyroptosis
lncRNA
Breast Cancer
RNA Name: 8 pyroptosis-related lncRNAs 0.0, AC004585.1, DLGAP1-AS1, TNFRSF14-AS1, AL606834.2, Z68871.1, AC009119.1, LINC01871, AL136368.1

Mechanism of Action: Risk model assessing immune infiltration and tumor microenvironment interactions

Effect on Cancer: Prognostic and therapeutic potential in breast cancer

PMID: 35702100
RP11-459E5.1, RP11-1070N10.3, RP11-817J15.3
lncRNA 		Identified via risk model correlating with immune checkpoints and mutation burden High correlation with survival outcomes PMID: 35360412

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Pyroptosis
lncRNA
Breast Cancer
RNA Name: RP11-459E5.1, RP11-1070N10.3, RP11-817J15.3

Mechanism of Action: Identified via risk model correlating with immune checkpoints and mutation burden

Effect on Cancer: High correlation with survival outcomes

PMID: 35360412