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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
UCA1
lncRNA
UCA1 functions as a competing endogenous RNA (ceRNA), UCA1 drives trastuzumab resistance and sustains breast cancer cell viability via the autophagy pathway. PMID: 29408336

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Autophagy
lncRNA
Breast Cancer

RNA Name: UCA1

Mechanism of Action: UCA1 functions as a competing endogenous RNA (ceRNA),

Effect on Cancer: UCA1 drives trastuzumab resistance and sustains breast cancer cell viability via the autophagy pathway.

PMID: 29408336
ZNF649-AS1
lncRNA
Promotes the transcriptional activity of the ATG5 gene By promoting autophagy, ZNF649-AS1 contributes to trastuzumab resistance PMID: 32735773

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Autophagy
lncRNA
Breast Cancer

RNA Name: ZNF649-AS1

Mechanism of Action: Promotes the transcriptional activity of the ATG5 gene

Effect on Cancer: By promoting autophagy, ZNF649-AS1 contributes to trastuzumab resistance

PMID: 32735773
OTUD6B
lncRNA
OTUD6B-AS1 acts as a competing endogenous RNA (ceRNA), binding to miR-26a-5p and sequestering it. OTUD6B-AS1 supports cancer cell survival by promoting autophagy PMID: 34740994

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Autophagy
lncRNA
Breast Cancer

RNA Name: OTUD6B

Mechanism of Action: OTUD6B-AS1 acts as a competing endogenous RNA (ceRNA), binding to miR-26a-5p and sequestering it.

Effect on Cancer: OTUD6B-AS1 supports cancer cell survival by promoting autophagy

PMID: 34740994
NAMPT
lncRNA
NAMPT-AS acts as a competing endogenous RNA (ceRNA) for miR-548b-3p NAMPT-AS/NAMPT upregulation activates the mTOR pathway, which suppresses autophagy. PMID: 34087784

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Autophagy
lncRNA
Breast Cancer

RNA Name: NAMPT

Mechanism of Action: NAMPT-AS acts as a competing endogenous RNA (ceRNA) for miR-548b-3p

Effect on Cancer: NAMPT-AS/NAMPT upregulation activates the mTOR pathway, which suppresses autophagy.

PMID: 34087784
XIST
lncRNA
Activation of c-Met can modulate autophagy. ncRNA XIST promotes brain metastasis in breast cancer PMID: 30026327

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Autophagy
lncRNA
Breast Cancer

RNA Name: XIST

Mechanism of Action: Activation of c-Met can modulate autophagy.

Effect on Cancer: ncRNA XIST promotes brain metastasis in breast cancer

PMID: 30026327
LUCAT1
lncRNA
LUCAT1 promotes breast cancer progression via the LUCAT1/miR-7-5p/SOX2 axis Promote breast cancer cell survival PMID:  33360049

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Autophagy
lncRNA
Breast Cancer

RNA Name: LUCAT1

Mechanism of Action: LUCAT1 promotes breast cancer progression via the LUCAT1/miR-7-5p/SOX2 axis

Effect on Cancer: Promote breast cancer cell survival

PBRC
lncRNA
Induces autophagy to promote breast cancer progression PRBC induces autophagy by modulating PABPC1-mediated mRNA stabilization PMID: 38366145

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Autophagy
lncRNA
Breast Cancer

RNA Name: PBRC

Mechanism of Action: Induces autophagy to promote breast cancer progression

Effect on Cancer: PRBC induces autophagy by modulating PABPC1-mediated mRNA stabilization

PMID: 38366145
LINC01016
lncRNA
Regulates autophagy through miR-302a-3p and SATB1 interaction. Associated with survival prognosis in breast cancer PMID: 33216456

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Autophagy
lncRNA
Breast Cancer

RNA Name: LINC01016

Mechanism of Action: Regulates autophagy through miR-302a-3p and SATB1 interaction.

Effect on Cancer: Associated with survival prognosis in breast cancer

PMID: 33216456
LINC00578
lncRNA
Induces autophagy-related oncogenic pathways Correlated with poor prognosis in breast cancer PMID: 33216456

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Autophagy
lncRNA
Breast Cancer

RNA Name: LINC00578

Mechanism of Action: Induces autophagy-related oncogenic pathways

Effect on Cancer: Correlated with poor prognosis in breast cancer

PMID: 33216456
LINC01614
lncRNA
Regulates SLC31A1 expression as part of the LINC01614/miR-204-5p/SLC31A1 axis Associated with poor prognosis and immune infiltration PMID: 37884650

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Cuproptosis
lncRNA
Breast Cancer

RNA Name: LINC01614

Mechanism of Action: Regulates SLC31A1 expression as part of the LINC01614/miR-204-5p/SLC31A1 axis

Effect on Cancer: Associated with poor prognosis and immune infiltration

PMID: 37884650