Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities
| RNA Name | Mechanism of Action | Effect on Cancer | Reference |
|---|---|---|---|
|
hsa-miR-216b-5p
miRNA |
Reexpression sensitizes trastuzumab-resistant cells by inducing necroptosis through STAT1, IRF9, and PKR. | Reduces drug resistance; promotes necroptosis in HER2+ breast cancer. | PMID: 37529418 |
External Database SearchDetailed Information
RNA Name:
hsa-miR-216b-5p
Mechanism of Action:
Reexpression sensitizes trastuzumab-resistant cells by inducing necroptosis through STAT1, IRF9, and PKR.
Effect on Cancer:
Reduces drug resistance; promotes necroptosis in HER2+ breast cancer.
PMID:
37529418
|
|||
|
miR-141-3p
miRNA |
Modulates RIPK1/RIPK3/MLKL axis, regulating necroptosis by inhibiting downstream signaling pathways. | Promotes tumor progression by targeting key tumor suppressors; associated with metastasis and poor prognosis. | PMID: 35371342 |
External Database SearchDetailed Information
RNA Name:
miR-141-3p
Mechanism of Action:
Modulates RIPK1/RIPK3/MLKL axis, regulating necroptosis by inhibiting downstream signaling pathways.
Effect on Cancer:
Promotes tumor progression by targeting key tumor suppressors; associated with metastasis and poor prognosis.
PMID:
35371342
|
|||
|
miR-148a-3p
miRNA |
Influences necroptosis by targeting inflammatory mediators involved in cell death pathways. | Acts as a tumor suppressor by inhibiting oncogene expression; downregulation linked to aggressive phenotypes. | PMID: 36965898 |
External Database SearchDetailed Information
RNA Name:
miR-148a-3p
Mechanism of Action:
Influences necroptosis by targeting inflammatory mediators involved in cell death pathways.
Effect on Cancer:
Acts as a tumor suppressor by inhibiting oncogene expression; downregulation linked to aggressive phenotypes.
PMID:
36965898
|
|||
|
miR-200a-5p
miRNA |
Regulates oxidative stress and necroptotic pathways by modulating MLKL phosphorylation and ROS production. | Inhibits epithelial-to-mesenchymal transition (EMT); its deregulation is linked to BRCA metastasis. | PMID: |
External Database SearchDetailed Information
RNA Name:
miR-200a-5p
Mechanism of Action:
Regulates oxidative stress and necroptotic pathways by modulating MLKL phosphorylation and ROS production.
Effect on Cancer:
Inhibits epithelial-to-mesenchymal transition (EMT); its deregulation is linked to BRCA metastasis.
|
|||
|
miR-223-3p
miRNA |
Affects necroptosis by targeting key necroptotic proteins like RIPK3 and MLKL, modulating inflammation-induced cell death | Plays a dual role; promotes or inhibits BRCA progression depending on context and targets. Identified as therapeutic. | PMID: 35371342 |
External Database SearchDetailed Information
RNA Name:
miR-223-3p
Mechanism of Action:
Affects necroptosis by targeting key necroptotic proteins like RIPK3 and MLKL, modulating inflammation-induced cell death
Effect on Cancer:
Plays a dual role; promotes or inhibits BRCA progression depending on context and targets. Identified as therapeutic.
PMID:
35371342
|
|||
|
miR-425-5p
miRNA |
Impacts necroptotic signaling by altering the expression of RIPK1 and related mediators. | Functions as an oncogenic miRNA; promotes BRCA cell proliferation and inhibits apoptosis. | PMID: |
External Database SearchDetailed Information
RNA Name:
miR-425-5p
Mechanism of Action:
Impacts necroptotic signaling by altering the expression of RIPK1 and related mediators.
Effect on Cancer:
Functions as an oncogenic miRNA; promotes BRCA cell proliferation and inhibits apoptosis.
|
|||
|
DDIT4-AS1
lncRNA |
Stabilizing DDIT4 mRNA, inhibiting mTOR signaling | Promotes progression and chemoresistance of TNBC | PMID: 37096846 |
External Database SearchDetailed Information
RNA Name:
DDIT4-AS1
Mechanism of Action:
Stabilizing DDIT4 mRNA, inhibiting mTOR signaling
Effect on Cancer:
Promotes progression and chemoresistance of TNBC
PMID:
37096846
|
|||
|
PRBC
lncRNA |
Interacts with PABPC1 to enhance RISC recruitment | Promotes progression | PMID: 38366145 |
External Database SearchDetailed Information
RNA Name:
PRBC
Mechanism of Action:
Interacts with PABPC1 to enhance RISC recruitment
Effect on Cancer:
Promotes progression
PMID:
38366145
|
|||
|
H19
lncRNA |
SAHH/DNMT3B axis, regulates Beclin1 methylation | Induces tamoxifen resistance | PMID: 31340867 |
External Database SearchDetailed Information
RNA Name:
H19
Mechanism of Action:
SAHH/DNMT3B axis, regulates Beclin1 methylation
Effect on Cancer:
Induces tamoxifen resistance
PMID:
31340867
|
|||
|
Linc00707
lncRNA |
Activates PI3K/AKT/mTOR pathway | Promotes TNBC progression | PMID: 38485945 |
External Database SearchDetailed Information
RNA Name:
Linc00707
Mechanism of Action:
Activates PI3K/AKT/mTOR pathway
Effect on Cancer:
Promotes TNBC progression
PMID:
38485945
|
|||