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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
miR-200c
miRNA
Reduces expression levels of LC3 and UBQLN1 PMID: 25044403

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-200c

Mechanism of Action: Reduces expression levels of LC3 and UBQLN1

Effect on Cancer:

PMID: 25044403
miR-27a
miRNA
miR-27a suppressed LC3-II and p62 expressions to inhibit autophagy and sensitized cancer cells to doxorubicin and paclitaxel PMID: 32066826

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-27a

Mechanism of Action: miR-27a suppressed LC3-II and p62 expressions to inhibit autophagy

Effect on Cancer: and sensitized cancer cells to doxorubicin and paclitaxel

PMID: 32066826
miR-129-5p
miRNA
miR-129-5p suppressed HMGB1 to inhibit autophagy sensitized breast cancer cells to taxol treatment PMID: 31664305

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-129-5p

Mechanism of Action: miR-129-5p suppressed HMGB1 to inhibit autophagy

Effect on Cancer: sensitized breast cancer cells to taxol treatment

PMID: 31664305
miR-489
miRNA
miR-489 downregulated ULK1 to block autophagy  sensitized breast cancer cells to doxorubicin treatment PMID: 29784669

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-489

Mechanism of Action: miR-489 downregulated ULK1 to block autophagy 

Effect on Cancer: sensitized breast cancer cells to doxorubicin treatment

PMID: 29784669
miR-23b-3p
miRNA
miR-23b-3p downregulated SLC6A14 to promote autophagy tamoxifen resistance PMID: 31269432

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-23b-3p

Mechanism of Action: miR-23b-3p downregulated SLC6A14 to promote autophagy

Effect on Cancer: tamoxifen resistance

PMID: 31269432
miR-21
miRNA
miR-21 could promote PI3K/AKT/mTOR pathway to inhibit autophagy promote resistance towards both tamoxifen and fulvestrant PMID: 26796263

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-21

Mechanism of Action: miR-21 could promote PI3K/AKT/mTOR pathway to inhibit autophagy

Effect on Cancer: promote resistance towards both tamoxifen and fulvestrant

PMID: 26796263
miR-101
miRNA
miR-101 suppressed ATG4D, STMN1 and RAB5A expressions to block autophagy  promote tamoxifen-induced cells death PMID: 21915098

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-101

Mechanism of Action: miR-101 suppressed ATG4D, STMN1 and RAB5A expressions to block autophagy 

Effect on Cancer: promote tamoxifen-induced cells death

PMID: 21915098
miR-125b-5p
miRNA
miR-125b-5p suppressed PAD2 expression to promote both autophagy and apoptosis.  sensitized cancer cells to both tamoxifen and docetaxel PMID: 31601253

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-125b-5p

Mechanism of Action: miR-125b-5p suppressed PAD2 expression to promote both autophagy and apoptosis. 

Effect on Cancer: sensitized cancer cells to both tamoxifen and docetaxel

PMID: 31601253
miR-26b
miRNA
miR-26b downregulated DRAM1 expression to inhibit autophagy  sensitize breast cancer cells to irradiation PMID: 29399189

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Autophagy
miRNA
Breast Cancer

RNA Name: miR-26b

Mechanism of Action: miR-26b downregulated DRAM1 expression to inhibit autophagy 

Effect on Cancer: sensitize breast cancer cells to irradiation

PMID: 29399189
miR-200c
miRNA
miR-200 downregulated UBQLN1 to block autophagy sensitized breast cancer cells to irradiation PMID: 25044403

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Detailed Information

Autophagy
miRNA
Breast Cancer

RNA Name: miR-200c

Mechanism of Action: miR-200 downregulated UBQLN1 to block autophagy

Effect on Cancer: sensitized breast cancer cells to irradiation

PMID: 25044403