Cell Death Database

RNA Name: USP24

Mechanism of Action: Deubiquitinase USP24 stabilizes DHODH protein in mitochondria, suppressing lipid peroxidation and ferroptosis in TNBC cells.

Effect on Cancer: Confers resistance to ferroptosis; targeting USP24 sensitizes TNBC cells to ferroptosis and impairs growth/migration.

PMID: 40715045

RNA Name: ALOX15B

Mechanism of Action: 15?lipoxygenase?2 that produces lipid hydroperoxides; IRF1?ALOX15B axis enhances ferroptosis.

Effect on Cancer: Overexpression/activation increases erastin?induced ferroptosis and suppresses TNBC progression in models.

PMID: 40749811

RNA Name: IRF1

Mechanism of Action: IFN-?/IRF1 transcriptionally activates ALOX15B, increases lipid peroxidation and sensitizes TNBC cells to ferroptosis (e.g., with erastin/RSL3).

Effect on Cancer: Promotes ferroptosis; suppresses TNBC growth and enhances responsiveness to IFN-?�based or ferroptosis-inducing therapies.

PMID: 40749811

RNA Name: ZEB1

Mechanism of Action: Oxidative stress�induced acetylation (K1108) drives a hybrid EMT state that establishes NADPH?driven redox capacity to circumvent ferroptosis.

Effect on Cancer: Promotes ferroptosis resistance and metastasis in TNBC; targeting this axis exposes a vulnerability.

PMID: 40850192

RNA Name: PTGS2

Mechanism of Action: PTGS2 (COX-2) is commonly upregulated during ferroptosis and is widely used as a transcriptional biomarker of ferroptotic lipid peroxidation (marker, not causal).

Effect on Cancer: Upregulated PTGS2 confirms ferroptosis in TNBC cells (e.g., after GPX4 knockdown or erastin-based strategies).

PMID: 31464035

RNA Name: PTGS2

Mechanism of Action: PTGS2 (COX-2) is commonly upregulated during ferroptosis and is widely used as a transcriptional biomarker of ferroptotic lipid peroxidation (marker, not causal).

Effect on Cancer: Upregulated PTGS2 confirms ferroptosis in TNBC cells (e.g., after GPX4 knockdown or erastin-based strategies).

PMID: 33014355

RNA Name: P53RRA

Mechanism of Action: Promotes ferroptosis and apoptosis by displacing p53 from G3BP1 complex, increasing nuclear retention of p53

Effect on Cancer: Tumor suppressor role; low expression correlates with poor survival

PMID: 29588351

RNA Name: DSCAM-AS1

Mechanism of Action: Inhibits erastin-induced ferroptosis via m6A-modification, enhancing SLC7A11 stability

Effect on Cancer: Promotes progression; overexpression indicates poor prognosis

PMID: 38833042

RNA Name: LINC00152

Mechanism of Action: Blocks tamoxifen-induced ferroptosis by destabilizing PDE4D, increasing cAMP/Ca2+ levels, and generating ROS

Effect on Cancer: Confers tamoxifen resistance; inhibition restores ferroptosis and sensitizes to treatment

PMID: 38879508

RNA Name: LncFASA

Mechanism of Action: Increases lipid peroxidation and disrupts ROS homeostasis by inhibiting PRDX1 activity

Effect on Cancer: Impaired growth of triple-negative breast cancer; high expression indicates better survival

PMID: 37955780