Cell Death Database

RNA Name: CAV1

Mechanism of Action: Caveolin?1 increases IFNGR1, amplifying IFN? signaling to inhibit system Xc? (SLC7A11), thereby promoting lipid peroxidation and ferroptosis.

Effect on Cancer: Overexpression of CAV1 promotes ferroptosis and suppresses breast tumor growth; study used TNBC cells (e.g., MDA?MB?231).

PMID: 39395272

RNA Name: VDAC1

Mechanism of Action: VDAC1 oligomerization on mitochondria promotes mitochondrial ROS release required for cysteine-deprivation/RSL3-induced ferroptosis.

Effect on Cancer: In MDA?MB?231/?468 TNBC cells, blocking VDAC1 oligomerization reduces ferroptosis; VDAC1 activity promotes ferroptosis.

PMID: 39521767

RNA Name: ELAVL1

Mechanism of Action: HuR (ELAVL1) inhibition reduces SLC7A11 and engages ferroptosis among multiple PCDs in breast cancer cells incl. MDA?MB?231

Effect on Cancer: ELAVL1 activity supports antioxidant defenses; its inhibition promotes ferroptosis and impairs TNBC cell growth (shown in MDA?MB?231)

PMID: 39627778

RNA Name: PRKAA2

Mechanism of Action: AMPK activation (by CAPE) promotes ROS/lipid peroxidation and downregulates GPX4/ferritin, inducing ferroptosis.

Effect on Cancer: Activation of AMPK triggers ferroptosis and suppresses TNBC growth in cell/xenograft models.

PMID: 39729481

RNA Name: PRKAA1

Mechanism of Action: AMPK activation (by CAPE) promotes ROS/lipid peroxidation and downregulates GPX4/ferritin, inducing ferroptosis.

Effect on Cancer: Activation of AMPK triggers ferroptosis and suppresses TNBC growth in cell/xenograft models.

PMID: 39729481

RNA Name: EGFR

Mechanism of Action: Cold atmospheric plasma (CAP) modulates EGFR Tyr1068 phosphorylation and potentiates erastin?induced lipid peroxidation/ROS, enhancing ferroptosis.

Effect on Cancer: Sensitizes TNBC cells to ferroptosis and inhibits growth in vitro/in vivo models.

PMID: 39781456

RNA Name: SLC38A1

Mechanism of Action: Glutamine transporter SNAT1; GluOC induces SLC38A1 (and SLC7A11) to suppress ferroptosis

Effect on Cancer: Upregulation inhibits ferroptosis and promotes survival of TNBC cells

PMID: 40075587

RNA Name: NEDD4L

Mechanism of Action: E3 ubiquitin ligase that promotes GPX4 ubiquitination and degradation, thereby enabling ferroptosis.

Effect on Cancer: In TNBC cells, resveratrol induces ferroptosis via NEDD4L-mediated GPX4 degradation, increasing lipid peroxidation and cell death.

PMID: 40316059

RNA Name: HIF1A

Mechanism of Action: Inhibition of the SUCNR1/PI3K/HIF?1? pathway lowers SLC7A11 and promotes ferroptosis.

Effect on Cancer: Blocking HIF?1? signaling induces ferroptosis and suppresses TNBC proliferation/migration in vitro and in vivo.

PMID: 40532859

RNA Name: DHODH

Mechanism of Action: Mitochondrial CoQH2 oxidoreductase that suppresses lipid peroxidation; USP24 deubiquitinates & stabilizes DHODH to block ferroptosis.

Effect on Cancer: Stabilized DHODH limits ferroptosis and supports TNBC growth; targeting USP24�DHODH restores ferroptotic sensitivity.

PMID: 40715045