Cell Death Database

RNA Name: ACSL4

Mechanism of Action: Ligates AA/AdA to PUFA?CoA enabling incorporation into phospholipids, creating ferroptosis?prone membranes.

Effect on Cancer: Required for thrombin?induced ferroptosis via cPLA2?/ACSL4 signaling in TNBC cells.

PMID: 37939630

RNA Name: TP53

Mechanism of Action: Wild?type p53 can repress SLC7A11 to promote ferroptosis; mutant p53 can block ferroptosis.

Effect on Cancer: Mutant p53 protects TNBC from ferroptosis; depletion restores ferroptotic sensitivity.

PMID: 38354236

RNA Name: ALOX12

Mechanism of Action: 12?lipoxygenase catalyzes PUFA?PE peroxidation to drive ferroptosis.

Effect on Cancer: Upregulated by SBFI26 in TNBC cells; promotes lipid peroxidation and ferroptotic death.

PMID: 38516826

RNA Name: ALOXE3

Mechanism of Action: Epidermal lipoxygenase implicated in lipid peroxide generation.

Effect on Cancer: Upregulated by SBFI26 alongside other LOX genes; associated with ferroptosis induction in TNBC cells.

PMID: 38516826

RNA Name: SAT1

Mechanism of Action: p53?responsive polyamine catabolic enzyme linked to lipid peroxidation (e.g., via ALOX15 pathway).

Effect on Cancer: In TNBC cells, SBFI26 elevates SAT1 expression during ferroptosis induction.

PMID: 38516826

RNA Name: BRCA1

Mechanism of Action: BRCA1 loss creates a vulnerability to ferroptosis; GPX4/PARP co-inhibition exploits ferroptotic susceptibility of BRCA1-deficient tumors.

Effect on Cancer: BRCA1-deficient TNBC models show heightened sensitivity to GPX4 inhibition (and PARP+GPX4 co-targeting), indicating enhanced ferroptosis.

PMID: 38552003

RNA Name: MTOR

Mechanism of Action: Inhibition of mTORC1 (downstream of MTOR) reduces SREBP1/SCD1 lipid synthesis, shifting lipids toward ferroptosis?prone species and triggering ferroptosis.

Effect on Cancer: Blocking mTORC1 signaling sensitizes TNBC cells to ferroptosis; formononetin triggers ferroptosis via mTORC1/SREBP1/SCD1 axis in TNBC.

PMID: 39399463

RNA Name: FADS1

Mechanism of Action: Desaturase shaping PUFA content; modulates availability of peroxidation substrates for ferroptosis.

Effect on Cancer: FADS1/2?high TNBC subtype is more susceptible to ferroptosis?inducing agents.

PMID: 38926633

RNA Name: EGR1

Mechanism of Action: EGR1 upregulation triggers ferroptosis by repressing NRF2�HMOX1 antioxidant axis and elevating lipid ROS in TNBC lines (MDA?MB?231/?468).

Effect on Cancer: Promotes ferroptosis; inhibits TNBC cell viability and tumor growth in models.

PMID: 27377973

RNA Name: NCOA4

Mechanism of Action: Cargo receptor mediating ferritinophagy; releases Fe2+ to fuel ferroptosis.

Effect on Cancer: Sulforaphene inhibits TNBC by activating Egr1

PMID: 39353532