Cell Death Database

RNA Name: miR-374c-5p

Mechanism of Action: Not reported

Effect on Cancer: Tumor suppressor: downregulated in BC; overexpression inhibits proliferation, migration and EMT, and induces apoptosis (via TAF7/DEPDC1)

PMID: 31162714

RNA Name: TFRC

Mechanism of Action: Transferrin receptor?1 imports iron and increases labile Fe2+, sensitizing to ferroptosis.

Effect on Cancer: ER?negative/TNBC cells with higher TFRC show greater sensitivity to sulfasalazine?induced ferroptosis.

PMID: 31173262

RNA Name: IFNG

Mechanism of Action: IFN??/JAK?STAT�IRF1 axis transcriptionally activates ALOX15B, enhancing lipid peroxidation and ferroptosis sensitivity in TNBC cells.

Effect on Cancer: Sensitizes TNBC cells to ferroptosis; tumor?suppressive.

PMID: 33495298

RNA Name: GSK3B

Mechanism of Action: Positive modulator of ferroptosis; active GSK3? disrupts iron homeostasis (affects DMT1/FTH1/FTL) to increase labile iron and ferroptosis sensitivity.

Effect on Cancer: In PTEN?KO MDA?MB?231 (TNBC) cells, increased pGSK3?Ser9 (inactive) associates with higher NRF2/xCT and resistance to ferroptosis; implies active GSK3? enhances sensitivity.

PMID: 34732689

RNA Name: TGFB1

Mechanism of Action: Part of IL?6?TGF??1?HLF axis from TAMs; HLF upregulates GGT1 to boost GSH, conferring ferroptosis resistance.

Effect on Cancer: Promotes ferroptosis resistance and malignant progression in TNBC via TAM?derived IL?6/TGF??1 signaling.

PMID: 34991659

RNA Name: IL6

Mechanism of Action: TNBC?secreted IL?6 activates TAMs to secrete TGF??1 ? activates HLF in tumor cells ? upregulates GGT1 ? suppresses ferroptosis.

Effect on Cancer: Confers ferroptosis resistance; promotes progression and chemoresistance.

PMID: 34991659

RNA Name: P4HB

Mechanism of Action: Protein disulfide isomerase (encoded by P4HB) is required for erastin-induced ferroptosis in MDA-MB-231 TNBC cells by promoting lipid ROS accumulation.

Effect on Cancer: Facilitates ferroptotic death upon erastin; PDI inhibition reduces ferroptosis in TNBC cells.

PMID: 30367042

RNA Name: HMOX1

Mechanism of Action: HO-1 (HMOX1) axis modulates ferroptosis; HO-1-dependent ferroptosis reported in TNBC cells

Effect on Cancer: HO-1 upregulation can mediate ferroptotic cell death (e.g., HCL-23 triggers HO-1-dependent ferroptosis in TNBC cells)

PMID: 37110625

RNA Name: SIRT3

Mechanism of Action: Drives autophagy?dependent ferroptosis by promoting BECN1?SLC7A11 complex formation (AMPK/mTOR axis).

Effect on Cancer: Enhances ferroptosis and anticancer activity in breast cancer models including TNBC cell lines.

PMID: 37196680

RNA Name: SOCS1

Mechanism of Action: Ferroptosis driver that downregulates GPX4/xCT, elevating lipid peroxidation.

Effect on Cancer: Overexpression induces ferroptosis, inhibits growth and cisplatin resistance in TNBC models.

PMID: 37665951