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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

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388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
KCNQ1OT1
lncRNA 		KCNQ1OT1 epigenetically inhibits ferroptosis. It recruits the methyltransferase MLL4 to the TRABD promoter, increasing H3K4 methylation and TRABD expression. Inhibition of KCNQ1OT1 (e.g. by ZC3H13-mediated m6A) restores ferroptosis. KCNQ1OT1 drives chemoresistance and growth in TNBC. Its activation of the TRABD axis promotes doxorubicin resistance; silencing KCNQ1OT1 (by ZC3H13) suppresses proliferation and induces ferroptosis in TNBC. PMID: 40000487

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

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Ferroptosis
lncRNA
Breast Cancer
RNA Name: KCNQ1OT1

Mechanism of Action: KCNQ1OT1 epigenetically inhibits ferroptosis. It recruits the methyltransferase MLL4 to the TRABD promoter, increasing H3K4 methylation and TRABD expression. Inhibition of KCNQ1OT1 (e.g. by ZC3H13-mediated m6A) restores ferroptosis.

Effect on Cancer: KCNQ1OT1 drives chemoresistance and growth in TNBC. Its activation of the TRABD axis promotes doxorubicin resistance; silencing KCNQ1OT1 (by ZC3H13) suppresses proliferation and induces ferroptosis in TNBC.

PMID: 40000487
miR-153
miRNA 		Reduces cell ferroptosis via circ_0000643/miR-153/SLC7A11 axis Inhibits ferroptosis and promotes progression PMID: 37591453

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-153

Mechanism of Action: Reduces cell ferroptosis via circ_0000643/miR-153/SLC7A11 axis

Effect on Cancer: Inhibits ferroptosis and promotes progression

PMID: 37591453
miR-335-5p
miRNA 		Regulates GPX4 via Sp1 transcription factor Induces ferroptosis and inhibits progression PMID: 38866351

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-335-5p

Mechanism of Action: Regulates GPX4 via Sp1 transcription factor

Effect on Cancer: Induces ferroptosis and inhibits progression

PMID: 38866351
miR-128-3p
miRNA 		Targets CD98hc, induces ferroptosis Promotes ferroptosis and reduces tumor burden PMID: 38734268

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

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Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-128-3p

Mechanism of Action: Targets CD98hc, induces ferroptosis

Effect on Cancer: Promotes ferroptosis and reduces tumor burden

PMID: 38734268
miR-376c-3p
miRNA 		Targets SLC7A11 to regulate ferroptosis Inhibits ferroptosis and supports tumor growth PMID: 38318853

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

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Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-376c-3p

Mechanism of Action: Targets SLC7A11 to regulate ferroptosis

Effect on Cancer: Inhibits ferroptosis and supports tumor growth

PMID: 38318853
miR-5096
miRNA 		Targets SLC7A11 and induces ferroptotic cell death Induces ferroptosis and reduces invasion PMID: 34571083

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-5096

Mechanism of Action: Targets SLC7A11 and induces ferroptotic cell death

Effect on Cancer: Induces ferroptosis and reduces invasion

PMID: 34571083
miR-324-3p
miRNA 		Targets GPX4 to induce ferroptosis Promotes ferroptosis and inhibits proliferation PMID: 33522578

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-324-3p

Mechanism of Action: Targets GPX4 to induce ferroptosis

Effect on Cancer: Promotes ferroptosis and inhibits proliferation

PMID: 33522578
miR-106a-5p
miRNA 		Regulates STAT3 to inhibit ferroptosis Supports progression by attenuating ferroptosis PMID: 33686957

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-106a-5p

Mechanism of Action: Regulates STAT3 to inhibit ferroptosis

Effect on Cancer: Supports progression by attenuating ferroptosis

PMID: 33686957
miR-382-5p
miRNA 		Down regulate the expression of SLC7A11 Block lidocaine induced ferroptosis PMID: 34122108

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-382-5p

Mechanism of Action: Down regulate the expression of SLC7A11

Effect on Cancer: Block lidocaine induced ferroptosis

PMID: 34122108
miR-133a
miRNA 		Decreased levels of ferritin light chain (FTL) protein Increases sensitivity for doxorubicin and cisplatin induced ferroptosis PMID: 23969999

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Ferroptosis
miRNA
Breast Cancer
RNA Name: miR-133a

Mechanism of Action: Decreased levels of ferritin light chain (FTL) protein

Effect on Cancer: Increases sensitivity for doxorubicin and cisplatin induced ferroptosis

PMID: 23969999