Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities
| RNA Name | Mechanism of Action | Effect on Cancer | Reference |
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P53RRA
lncRNA |
Promotes ferroptosis and apoptosis by displacing p53 from G3BP1 complex, increasing nuclear retention of p53 | Tumor suppressor role; low expression correlates with poor survival | PMID: 29588351 |
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RNA Name:
P53RRA
Mechanism of Action:
Promotes ferroptosis and apoptosis by displacing p53 from G3BP1 complex, increasing nuclear retention of p53
Effect on Cancer:
Tumor suppressor role; low expression correlates with poor survival
PMID:
29588351
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DSCAM-AS1
lncRNA |
Inhibits erastin-induced ferroptosis via m6A-modification, enhancing SLC7A11 stability | Promotes progression; overexpression indicates poor prognosis | PMID: 38833042 |
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RNA Name:
DSCAM-AS1
Mechanism of Action:
Inhibits erastin-induced ferroptosis via m6A-modification, enhancing SLC7A11 stability
Effect on Cancer:
Promotes progression; overexpression indicates poor prognosis
PMID:
38833042
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LINC00152
lncRNA |
Blocks tamoxifen-induced ferroptosis by destabilizing PDE4D, increasing cAMP/Ca2+ levels, and generating ROS | Confers tamoxifen resistance; inhibition restores ferroptosis and sensitizes to treatment | PMID: 38879508 |
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RNA Name:
LINC00152
Mechanism of Action:
Blocks tamoxifen-induced ferroptosis by destabilizing PDE4D, increasing cAMP/Ca2+ levels, and generating ROS
Effect on Cancer:
Confers tamoxifen resistance; inhibition restores ferroptosis and sensitizes to treatment
PMID:
38879508
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LncFASA
lncRNA |
Increases lipid peroxidation and disrupts ROS homeostasis by inhibiting PRDX1 activity | Impaired growth of triple-negative breast cancer; high expression indicates better survival | PMID: 37955780 |
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RNA Name:
LncFASA
Mechanism of Action:
Increases lipid peroxidation and disrupts ROS homeostasis by inhibiting PRDX1 activity
Effect on Cancer:
Impaired growth of triple-negative breast cancer; high expression indicates better survival
PMID:
37955780
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PTPRG-AS1
lncRNA |
Inhibits ferroptosis via miR-376c-3p/SLC7A11 axis | Promotes triple-negative breast cancer development | PMID: 38318853 |
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RNA Name:
PTPRG-AS1
Mechanism of Action:
Inhibits ferroptosis via miR-376c-3p/SLC7A11 axis
Effect on Cancer:
Promotes triple-negative breast cancer development
PMID:
38318853
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HCP5
lncRNA |
Regulating GPX4 expression and lipid ROS level | Inhibits ferroptosis | PMID: 36980766 |
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RNA Name:
HCP5
Mechanism of Action:
Regulating GPX4 expression and lipid ROS level
Effect on Cancer:
Inhibits ferroptosis
PMID:
36980766
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LINC00460
lncRNA |
LINC00460 knockdown suppressed proliferation of breast cancer cells and promoted ferroptosis | Inhibits cancer ferroptosis | PMID: 36938678 |
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RNA Name:
LINC00460
Mechanism of Action:
LINC00460 knockdown suppressed proliferation of breast cancer cells and promoted ferroptosis
Effect on Cancer:
Inhibits cancer ferroptosis
PMID:
36938678
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H19
lncRNA |
H19 regulates ferroptosis via autophagy. Metformin-induced ferroptosis is mediated by inhibiting autophagy through H19; knockdown of H19 enhances lipid-ROS accumulation and ferroptosis. | H19 is oncogenic in breast cancer – its overexpression promotes tumorigenesis. In BC models H19 overexpression increases proliferation and invasion. | PMID: 34644456 |
External Database SearchDetailed Information
RNA Name:
H19
Mechanism of Action:
H19 regulates ferroptosis via autophagy. Metformin-induced ferroptosis is mediated by inhibiting autophagy through H19; knockdown of H19 enhances lipid-ROS accumulation and ferroptosis.
Effect on Cancer:
H19 is oncogenic in breast cancer – its overexpression promotes tumorigenesis. In BC models H19 overexpression increases proliferation and invasion.
PMID:
34644456
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NEAT1
lncRNA |
NEAT1 acts as a ceRNA to promote ferroptosis. It sponges miR-362-3p to upregulate MIOX, which raises ROS and depletes GSH, thereby enhancing erastin/RSL3-induced ferroptosis. | NEAT1 is pro-tumorigenic in BC. It promotes cell proliferation, migration, invasion, and metastasis; knockdown of NEAT1 suppresses these malignant phenotypes. | PMID: 35338333 |
External Database SearchDetailed Information
RNA Name:
NEAT1
Mechanism of Action:
NEAT1 acts as a ceRNA to promote ferroptosis. It sponges miR-362-3p to upregulate MIOX, which raises ROS and depletes GSH, thereby enhancing erastin/RSL3-induced ferroptosis.
Effect on Cancer:
NEAT1 is pro-tumorigenic in BC. It promotes cell proliferation, migration, invasion, and metastasis; knockdown of NEAT1 suppresses these malignant phenotypes.
PMID:
35338333
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NEAT1
lncRNA |
NEAT1 acts as a ceRNA to promote ferroptosis. It sponges miR-362-3p to upregulate MIOX, which raises ROS and depletes GSH, thereby enhancing erastin/RSL3-induced ferroptosis. | NEAT1 is pro-tumorigenic in BC. It promotes cell proliferation, migration, invasion, and metastasis; knockdown of NEAT1 suppresses these malignant phenotypes. | PMID: 32801860 |
External Database SearchDetailed Information
RNA Name:
NEAT1
Mechanism of Action:
NEAT1 acts as a ceRNA to promote ferroptosis. It sponges miR-362-3p to upregulate MIOX, which raises ROS and depletes GSH, thereby enhancing erastin/RSL3-induced ferroptosis.
Effect on Cancer:
NEAT1 is pro-tumorigenic in BC. It promotes cell proliferation, migration, invasion, and metastasis; knockdown of NEAT1 suppresses these malignant phenotypes.
PMID:
32801860
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