Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities
| RNA Name | Mechanism of Action | Effect on Cancer | Reference |
|---|---|---|---|
|
BCL2
mRNA |
BCL-2 binds BECN1 to inhibit autophagy; BCL-2 inhibition can derepress autophagy. | BCL2 suppresses autophagy in MCF7 breast cancer cells by binding to Beclin-1, and this suppression enhances tumor cell growth. | PMID: 20885445 |
External Database SearchDetailed Information
RNA Name:
BCL2
Mechanism of Action:
BCL-2 binds BECN1 to inhibit autophagy; BCL-2 inhibition can derepress autophagy.
Effect on Cancer:
BCL2 suppresses autophagy in MCF7 breast cancer cells by binding to Beclin-1, and this suppression enhances tumor cell growth.
PMID:
20885445
|
|||
|
HSPA8
mRNA |
HSPA8 was mainly involved in partner-mediated autophagy | In (TNBC), HSPA8 is overexpressed and emerges as a key biomarker linked to poor prognosis, immune infiltration, and clinicopathological features. | PMID: 36452344 |
External Database SearchDetailed Information
RNA Name:
HSPA8
Mechanism of Action:
HSPA8 was mainly involved in partner-mediated autophagy
Effect on Cancer:
In (TNBC), HSPA8 is overexpressed and emerges as a key biomarker linked to poor prognosis, immune infiltration, and clinicopathological features.
PMID:
36452344
|
|||
|
LEPR
mRNA |
Autophagy activation and SREBP-1 induction, leading to stimulated cell proliferation | Elicits metabolic reprogramming in breast cancer. | PMID: 33799880 |
External Database SearchDetailed Information
RNA Name:
LEPR
Mechanism of Action:
Autophagy activation and SREBP-1 induction, leading to stimulated cell proliferation
Effect on Cancer:
Elicits metabolic reprogramming in breast cancer.
PMID:
33799880
|
|||
|
PINK1
mRNA |
Kinase that initiates PRKN-dependent mitophagy on damaged mitochondria. | PINK1/PRKN mitophagy supports TNBC cell survival and chemoresistance; inhibiting this axis sensitizes cells to therapy. | PMID: 33929971 |
External Database SearchDetailed Information
RNA Name:
PINK1
Mechanism of Action:
Kinase that initiates PRKN-dependent mitophagy on damaged mitochondria.
Effect on Cancer:
PINK1/PRKN mitophagy supports TNBC cell survival and chemoresistance; inhibiting this axis sensitizes cells to therapy.
PMID:
33929971
|
|||
|
STING1
mRNA |
cGAS�STING signaling supports TNBC growth; pathway inhibition triggers autophagy-dependent cell death, implicating autophagy in STING-driven survival. | Pro-survival pathway in TNBC; blocking STING induces autophagy-dependent death in TNBC models. | PMID: 35992877 |
External Database SearchDetailed Information
RNA Name:
STING1
Mechanism of Action:
cGAS�STING signaling supports TNBC growth; pathway inhibition triggers autophagy-dependent cell death, implicating autophagy in STING-driven survival.
Effect on Cancer:
Pro-survival pathway in TNBC; blocking STING induces autophagy-dependent death in TNBC models.
PMID:
35992877
|
|||
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | PMID: 35467897 |
External Database SearchDetailed Information
RNA Name:
SMURF1
Mechanism of Action:
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC
Effect on Cancer:
Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA.
PMID:
35467897
|
|||
|
SMURF1
mRNA |
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC | Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA. | PMID: 28017659 |
External Database SearchDetailed Information
RNA Name:
SMURF1
Mechanism of Action:
E3 ubiquitin ligase regulating autophagy and metastasis in TNBC
Effect on Cancer:
Plays a role in breast cancer cell migration and invasion through the downregulation of RhoA.
PMID:
28017659
|
|||
|
HK2
mRNA |
HK2 is targeted by miR-216b, leading to inhibition of the mTOR pathway, which in turn stimulates autophagy | miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC | PMID: 34345220 |
External Database SearchDetailed Information
RNA Name:
HK2
Mechanism of Action:
HK2 is targeted by miR-216b, leading to inhibition of the mTOR pathway, which in turn stimulates autophagy
Effect on Cancer:
miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC
PMID:
34345220
|
|||
|
TOLLIP
mRNA |
Autophagy receptor mediating selective autophagic degradation of TMEM63A/DERL1 axis. | TOLLIP-mediated autophagic degradation pathway drives TNBC progression; disrupting VCP/TMEM63A/DERL1 reduces oncogenic effects in vitro and in vivo. | PMID: 35920704 |
External Database SearchDetailed Information
RNA Name:
TOLLIP
Mechanism of Action:
Autophagy receptor mediating selective autophagic degradation of TMEM63A/DERL1 axis.
Effect on Cancer:
TOLLIP-mediated autophagic degradation pathway drives TNBC progression; disrupting VCP/TMEM63A/DERL1 reduces oncogenic effects in vitro and in vivo.
PMID:
35920704
|
|||
|
NOD2
mRNA |
NOD2 drives innate immune signaling and autophagy in cancer | Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role. | PMID: 29615116 |
External Database SearchDetailed Information
RNA Name:
NOD2
Mechanism of Action:
NOD2 drives innate immune signaling and autophagy in cancer
Effect on Cancer:
Overexpression of NOD2 in breast cancer cell lines decreases proliferation, suggesting a tumor-suppressor role.
PMID:
29615116
|
|||