Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities
| RNA Name | Mechanism of Action | Effect on Cancer | Reference |
|---|---|---|---|
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BECN1
mRNA |
Core autophagy regulator; forms complexes with class III PI3K to initiate autophagosome formation. | Beclin1 regulates autophagy-mediated survival in TNBC; loss or suppression sensitizes to chemotherapy. | PMID: 22733132 |
External Database SearchDetailed Information
RNA Name:
BECN1
Mechanism of Action:
Core autophagy regulator; forms complexes with class III PI3K to initiate autophagosome formation.
Effect on Cancer:
Beclin1 regulates autophagy-mediated survival in TNBC; loss or suppression sensitizes to chemotherapy.
PMID:
22733132
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MTOR
mRNA |
AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis | The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition | PMID: 27526942 |
External Database SearchDetailed Information
RNA Name:
MTOR
Mechanism of Action:
AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis
Effect on Cancer:
The combination of tamoxifen and CSC-3436 produced stronger tumor growth inhibition
PMID:
27526942
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USP10
mRNA |
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy. | USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1. | PMID: 21962518 |
External Database SearchDetailed Information
RNA Name:
USP10
Mechanism of Action:
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy.
Effect on Cancer:
USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1.
PMID:
21962518
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USP10
mRNA |
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy. | USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1. | PMID: 36248971 |
External Database SearchDetailed Information
RNA Name:
USP10
Mechanism of Action:
Deubiquitinase stabilizing Beclin1 and p53, promoting autophagy.
Effect on Cancer:
USP10 promotes autophagy and chemoresistance in TNBC cells by stabilizing Beclin1.
PMID:
36248971
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ELAPOR1 (EVA1A)
mRNA |
EVA1A positively regulates autophagy/mitophagy; flubendazole targets EVA1A to trigger excessive autophagy/mitophagy. | Anti-tumor via autophagy: EVA1A-driven (flubendazole-induced) autophagy/mitophagy suppresses TNBC proliferation and migration. | PMID: 32724459 |
External Database SearchDetailed Information
RNA Name:
ELAPOR1 (EVA1A)
Mechanism of Action:
EVA1A positively regulates autophagy/mitophagy; flubendazole targets EVA1A to trigger excessive autophagy/mitophagy.
Effect on Cancer:
Anti-tumor via autophagy: EVA1A-driven (flubendazole-induced) autophagy/mitophagy suppresses TNBC proliferation and migration.
PMID:
32724459
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TMEM41B
mRNA |
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis. | Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B | PMID: 39709500 |
External Database SearchDetailed Information
RNA Name:
TMEM41B
Mechanism of Action:
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis.
Effect on Cancer:
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B
PMID:
39709500
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TMEM41B
mRNA |
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis. | Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B | PMID: 36931971 |
External Database SearchDetailed Information
RNA Name:
TMEM41B
Mechanism of Action:
ER-resident lipid scramblase required for autophagosome formation; loss blocks autophagosome biogenesis.
Effect on Cancer:
Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B
PMID:
36931971
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ATG2B
mRNA |
In TNBC cancer stem cells (CSCs), autophagy is suppressed via upregulation of miR-181a, which directly targets ATG5 and ATG2B, reducing their expression and dampening autophagy | Same study shows miR?181a suppresses ATG2B to inhibit autophagy and TNBC stemness/tumorigenicity. | PMID: 35029026 |
External Database SearchDetailed Information
RNA Name:
ATG2B
Mechanism of Action:
In TNBC cancer stem cells (CSCs), autophagy is suppressed via upregulation of miR-181a, which directly targets ATG5 and ATG2B, reducing their expression and dampening autophagy
Effect on Cancer:
Same study shows miR?181a suppresses ATG2B to inhibit autophagy and TNBC stemness/tumorigenicity.
PMID:
35029026
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CASP3
mRNA |
Promote cytoprotective autophagy under non-lethal stresses like starvation or proteasome inhibition. | Caspase-3�mediated cleavage of autophagy proteins linked to TNBC apoptosis�autophagy balance and treatment responses. | PMID: 39982959 |
External Database SearchDetailed Information
RNA Name:
CASP3
Mechanism of Action:
Promote cytoprotective autophagy under non-lethal stresses like starvation or proteasome inhibition.
Effect on Cancer:
Caspase-3�mediated cleavage of autophagy proteins linked to TNBC apoptosis�autophagy balance and treatment responses.
PMID:
39982959
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SNAP29
mRNA |
SNARE protein that mediates autophagosome�lysosome fusion. | SNAP29 is essential for autophagic flux in TNBC; silencing impairs autophagy and suppresses tumor cell survival. | PMID: 35256275 |
External Database SearchDetailed Information
RNA Name:
SNAP29
Mechanism of Action:
SNARE protein that mediates autophagosome�lysosome fusion.
Effect on Cancer:
SNAP29 is essential for autophagic flux in TNBC; silencing impairs autophagy and suppresses tumor cell survival.
PMID:
35256275
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