Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities
| RNA Name | Mechanism of Action | Effect on Cancer | Reference |
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RPTOR
mRNA |
Scaffold of mTORC1; activation suppresses autophagy via ULK1 inhibition. | In TNBC cells, RPTOR inhibition overcame resistance to EGFR inhibition (gefitinib), reducing viability and signaling. | PMID: 29344641 |
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RNA Name:
RPTOR
Mechanism of Action:
Scaffold of mTORC1; activation suppresses autophagy via ULK1 inhibition.
Effect on Cancer:
In TNBC cells, RPTOR inhibition overcame resistance to EGFR inhibition (gefitinib), reducing viability and signaling.
PMID:
29344641
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FOXO3
mRNA |
Luteolin treatments suppress SGK1, which allows FOXO3a to move into the nucleus and upregulate BNIP3; this triggers autophagy | Luteolin induces autophagy in TNBC via SGK1-FOXO3a-BNIP3 signaling | PMID: 37346292 |
External Database SearchDetailed Information
RNA Name:
FOXO3
Mechanism of Action:
Luteolin treatments suppress SGK1, which allows FOXO3a to move into the nucleus and upregulate BNIP3; this triggers autophagy
Effect on Cancer:
Luteolin induces autophagy in TNBC via SGK1-FOXO3a-BNIP3 signaling
PMID:
37346292
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USP20
mRNA |
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation. | USP20 promotes migration/invasion in breast cancer | PMID: 32943575 |
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RNA Name:
USP20
Mechanism of Action:
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation.
Effect on Cancer:
USP20 promotes migration/invasion in breast cancer
PMID:
32943575
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USP20
mRNA |
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation. | USP20 promotes migration/invasion in breast cancer | PMID: 29487085 |
External Database SearchDetailed Information
RNA Name:
USP20
Mechanism of Action:
Deubiquitinates and stabilizes ULK1, positively regulating autophagy initiation.
Effect on Cancer:
USP20 promotes migration/invasion in breast cancer
PMID:
29487085
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HDAC6
mRNA |
Cytoplasmic deacetylase that regulates autophagosome�lysosome fusion and autophagic flux. | Sulforaphane induces autophagy and suppresses TNBC cell growth via inhibition of HDAC6-mediated PTEN activation (MDA-MB-231/468). | PMID: 30352240 |
External Database SearchDetailed Information
RNA Name:
HDAC6
Mechanism of Action:
Cytoplasmic deacetylase that regulates autophagosome�lysosome fusion and autophagic flux.
Effect on Cancer:
Sulforaphane induces autophagy and suppresses TNBC cell growth via inhibition of HDAC6-mediated PTEN activation (MDA-MB-231/468).
PMID:
30352240
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DNM2
mRNA |
Dynamin?2 regulates autophagosome formation/ATG9 trafficking; dynamin inhibition impairs autophagy. | In TNBC derivatives (MDA?MB?231?BR3), DNM2 knockdown impairs homologous recombination and increases sensitivity to PARP inhibitors. | PMID: 30371505 |
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RNA Name:
DNM2
Mechanism of Action:
Dynamin?2 regulates autophagosome formation/ATG9 trafficking; dynamin inhibition impairs autophagy.
Effect on Cancer:
In TNBC derivatives (MDA?MB?231?BR3), DNM2 knockdown impairs homologous recombination and increases sensitivity to PARP inhibitors.
PMID:
30371505
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SLC7A5
mRNA |
LAT1-mediated essential amino acid uptake activates mTORC1; LAT1 inhibition can reduce mTORC1 signaling and trigger autophagy. | Overexpressed in TNBC; higher LAT1 correlates with poor prognosis and is a therapeutic target in TNBC models. | PMID: |
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RNA Name:
SLC7A5
Mechanism of Action:
LAT1-mediated essential amino acid uptake activates mTORC1; LAT1 inhibition can reduce mTORC1 signaling and trigger autophagy.
Effect on Cancer:
Overexpressed in TNBC; higher LAT1 correlates with poor prognosis and is a therapeutic target in TNBC models.
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HMGB1
mRNA |
Upregulates autophagy via HMGB1�Beclin1 axis; miR-107 targeting HMGB1 reduces autophagy markers (LC3-II) in MDA-MB-231 cells. | Promotes migration/survival; HMGB1 suppression (by miR-107) decreases autophagy and migration in MDA-MB-231 (TNBC). | PMID: 30506984 |
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RNA Name:
HMGB1
Mechanism of Action:
Upregulates autophagy via HMGB1�Beclin1 axis; miR-107 targeting HMGB1 reduces autophagy markers (LC3-II) in MDA-MB-231 cells.
Effect on Cancer:
Promotes migration/survival; HMGB1 suppression (by miR-107) decreases autophagy and migration in MDA-MB-231 (TNBC).
PMID:
30506984
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ATG9A
mRNA |
Only multi-pass transmembrane ATG protein; supplies membrane for autophagosome biogenesis. | ATG9A is overexpressed in TNBC; knockdown reduces autophagy, migration and colony formation, indicating a pro-tumor role. | PMID: 30563263 |
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RNA Name:
ATG9A
Mechanism of Action:
Only multi-pass transmembrane ATG protein; supplies membrane for autophagosome biogenesis.
Effect on Cancer:
ATG9A is overexpressed in TNBC; knockdown reduces autophagy, migration and colony formation, indicating a pro-tumor role.
PMID:
30563263
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LGALS8
mRNA |
Galectin-8 senses damaged endomembranes and promotes selective autophagy by recruiting autophagy adaptors to ruptured vesicles. | Dual knockdown of LGALS8 and its ligand ALCAM reduces tumor growth and lung metastasis in TNBC models (MDA?MB?231). | PMID: 30905597 |
External Database SearchDetailed Information
RNA Name:
LGALS8
Mechanism of Action:
Galectin-8 senses damaged endomembranes and promotes selective autophagy by recruiting autophagy adaptors to ruptured vesicles.
Effect on Cancer:
Dual knockdown of LGALS8 and its ligand ALCAM reduces tumor growth and lung metastasis in TNBC models (MDA?MB?231).
PMID:
30905597
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