Cell Death Database

RNA Name: hsa-miR-21-5p

Mechanism of Action: Knockdown increases autophagy via inhibition of PI3K/AKT/mTOR (?Beclin-1, ?LC3-II), enhancing endocrine-therapy-induced autophagic cell death.

Effect on Cancer: Sensitizes ER+ breast cancer cells to tamoxifen/fulvestrant; promotes autophagy when inhibited.

PMID: 26796263

RNA Name: hsa-miR-20b-5p

Mechanism of Action: Suppresses autophagy by targeting RB1CC1/FIP200, reducing LC3-II (shown in MDA-MB-231).

Effect on Cancer: Autophagy inhibition supports proliferation/survival in the TNBC cell line MDA?MB?231.

PMID: 26829385

RNA Name: hsa-miR-96-5p

Mechanism of Action: Inhibits autophagy by directly targeting FOXO1; reduces LC3-II and increases p62 in MDA-MB-231 under starvation

Effect on Cancer: Pro-tumorigenic: enhances proliferation, migration, and invasion; suppresses apoptosis in MDA-MB-231

PMID: 28588711

RNA Name: hsa-miR-20a-5p

Mechanism of Action: Inhibits the basal and nutrient starvation-induced autophagic flux and lysosomal proteolytic activity

Effect on Cancer: miR-20a promotes tumor initiation and tumor growth.

PMID: 28628113

RNA Name: hsa-miR-23a-3p

Mechanism of Action: Promotes autophagy and inhibits apoptosis via XIAP/Autophagy pathway in breast cancer cells.

Effect on Cancer: Pro-survival autophagy; may contribute to therapy resistance.

PMID: 28671686

RNA Name: hsa-miR-495-3p

Mechanism of Action: miR-495-3p mimics downregulate GRP78 and reduce p?AKT/mTOR signaling (autophagy-related pathway) in a TNBC drug-resistance model.

Effect on Cancer: Sensitizes TNBC cells to pirarubicin and reverses drug resistance.

PMID: 34935899

RNA Name: hsa-miR-181a-5p

Mechanism of Action: Suppresses autophagy via direct repression of ATG5 and/or ATG2B.

Effect on Cancer: Reduces autophagy, increasing cancer stemness and aggressive features in TNBC.

PMID: 35029026

RNA Name: hsa-miR-30a-5p

Mechanism of Action: miR-30a-3p negatively regulated autophagy by autophagy related 12 (Atg12)

Effect on Cancer: Altered mammary structure in the involution of the mammary glands of mice, which was indicative of alteration in mammary remodeling

PMID: 37762652

RNA Name: hsa-miR-4295

Mechanism of Action: Targets ITPR1 to suppress autophagy; RMST lncRNA sponges miR-4295, restoring ITPR1 and increasing autophagic flux (?LC3-II/I, ?p62).

Effect on Cancer: miR-4295 promotes proliferation/migration; RMST/ITPR1 counteracts this and suppresses TNBC progression via pro-autophagic signaling.

PMID: 40287640

RNA Name: hsa-miR-27a-3p

Mechanism of Action: Promotes autophagy by targeting/relieving BNIP3; CAF exosomal circFOXO1 lowers miR-27a-3p, increasing BNIP3 and autophagy during radiotherapy.

Effect on Cancer: Increases radioresistance and pro?tumor traits in TNBC (MDA?MB?231); autophagy inhibition (3?MA) weakens these effects.

PMID: 40784956