Cell Death Database

RNA Name: BCL2L14

Mechanism of Action: BCL2L14 (BCL-G) is a BCL-2 family member with pro-apoptotic BH3-like activity in certain contexts, promoting mitochondrial apoptosis when active.

Effect on Cancer: BCL2L14 fusions/alterations have been observed in aggressive breast cancers; linked to therapy resistance features.

PMID: 32321829

RNA Name: CASP2

Mechanism of Action: Caspase-2 acts as a stress-response initiator caspase involved in DNA damage-induced apoptosis and can function upstream of mitochondrial pathways.

Effect on Cancer: Altered CASP2 expression associates with prognosis in breast cancer/TNBC; functional context varies by study.

PMID: 37093683

RNA Name: CCAR2

Mechanism of Action: Inhibits SIRT1 to stabilize p53 and promote p53-mediated apoptosis; also coactivates ER?/PEA3 under some contexts.

Effect on Cancer: Dual role in breast cancer; linked to prognosis and can modulate apoptosis in BC.

PMID: 37524873

RNA Name: BCL2L1

Mechanism of Action: BCL2L1 (BCL-xL) is an anti-apoptotic Bcl-2 family protein that sequesters pro-apoptotic BH3-only proteins and Bax/Bak to prevent MOMP and apoptosis.

Effect on Cancer: Overexpression in TNBC contributes to chemoresistance; BCL-xL inhibition enhances apoptosis and chemosensitivity.

PMID: 38898061

RNA Name: CASP10

Mechanism of Action: Initiator caspase in extrinsic apoptosis (death receptor pathway).

Effect on Cancer: Expression observed in TNBC; functional studies limited in last 10 years but expression associated with apoptosis responses.

PMID: 40806590

RNA Name: H19

Mechanism of Action: Promotes protective autophagy by inhibiting SAHH, causing SAH accumulation that prevents DNMT3B-mediated methylation of the BECN1 promoter, upregulating Beclin1 and activating autophagy.

Effect on Cancer: Drives tamoxifen resistance in ER+ breast cancer via increased autophagy.

PMID: 31340867

RNA Name: hsa-miR-221-3p

Mechanism of Action: Targets p27^Kip1; associated with autophagic cell death signaling in MCF-7 context (reviews).

Effect on Cancer: Confers tamoxifen resistance in ER+ breast cancer via p27^Kip1 downregulation; autophagy implicated.

PMID: 18708351

RNA Name: hsa-miR-222-3p

Mechanism of Action: Targets p27^Kip1; linked with autophagy modulation in MCF-7 per reviews.

Effect on Cancer: Confers tamoxifen resistance in ER+ breast cancer via p27^Kip1 downregulation; autophagy implicated.

PMID: 18708351

RNA Name: hsa-miR-200c-3p

Mechanism of Action: Inhibits irradiation?induced autophagy by targeting UBQLN1; enhances radiosensitivity.

Effect on Cancer: In MDA?MB?231/BT549 (TNBC) cells, miR?200c overexpression reduces autophagy and increases radiosensitivity.

PMID: 25044403

RNA Name: hsa-miR-129-5p

Mechanism of Action: Attenuates irradiation?induced autophagy by directly targeting HMGB1; increases radiosensitivity.

Effect on Cancer: In MDA?MB?231 (TNBC) cells, overexpression inhibits autophagy and sensitizes to radiation.

PMID: 26720492