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Cell Death Database

Comprehensive RNA involved in Cell Death Pathways research database with advanced search and filtering capabilities

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388 research entries found
RNA Name Mechanism of Action Effect on Cancer Reference
hsa-miR-320d
miRNA 		Targets SOX4 (by lncRNA HNF1A-AS1) Tumor suppressor; inhibits proliferation and induces apoptosis (results retracted) PMID: 35539662

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-320d

Mechanism of Action: Targets SOX4 (by lncRNA HNF1A-AS1)

Effect on Cancer: Tumor suppressor; inhibits proliferation and induces apoptosis (results retracted)

PMID: 35539662
hsa-miR-326
miRNA 		Targets SOX12 (oncogene) Tumor suppressor; inhibits proliferation and migration (results retracted) PMID: 31311830

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-326

Mechanism of Action: Targets SOX12 (oncogene)

Effect on Cancer: Tumor suppressor; inhibits proliferation and migration (results retracted)

PMID: 31311830
hsa-miR-328-5p
miRNA 		Targets RAGE (receptor for AGE) Tumor suppressor; inhibits proliferation and drug resistance PMID: 29620238

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-328-5p

Mechanism of Action: Targets RAGE (receptor for AGE)

Effect on Cancer: Tumor suppressor; inhibits proliferation and drug resistance

PMID: 29620238
hsa-miR-340-5p
miRNA 		Targets LGR5 (Wnt/β-catenin pathway) Tumor suppressor; inhibits proliferation and drug resistance PMID: 30300682

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-340-5p

Mechanism of Action: Targets LGR5 (Wnt/β-catenin pathway)

Effect on Cancer: Tumor suppressor; inhibits proliferation and drug resistance

PMID: 30300682
hsa-miR-383-5p
miRNA 		Targets PD-L1 (immune checkpoint) Tumor suppressor; inhibits proliferation/migration and induces apoptosis PMID: 33359245

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-383-5p

Mechanism of Action: Targets PD-L1 (immune checkpoint)

Effect on Cancer: Tumor suppressor; inhibits proliferation/migration and induces apoptosis

PMID: 33359245
hsa-miR-448
miRNA 		Hsa-miR-448 suppresses KDM5B expression in TNBC, which downregulates MALAT-mediated oncogenic functions Tumor suppressor; inhibits growth and sensitizes to chemotherapy PMID: 40318146

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-448

Mechanism of Action: Hsa-miR-448 suppresses KDM5B expression in TNBC, which downregulates MALAT-mediated oncogenic functions

Effect on Cancer: Tumor suppressor; inhibits growth and sensitizes to chemotherapy

PMID: 40318146
hsa-miR-96-5p
miRNA 		Targets FOXO1, PTEN and others (PI3K/AKT) and inhibits apoptosis Oncogenic; promotes proliferation, invasion and chemoresistance PMID: 28588711

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
miRNA
Breast Cancer
RNA Name: hsa-miR-96-5p

Mechanism of Action: Targets FOXO1, PTEN and others (PI3K/AKT) and inhibits apoptosis

Effect on Cancer: Oncogenic; promotes proliferation, invasion and chemoresistance

PMID: 28588711
ZC3H12A
mRNA 		RNase MCPIP1; degrades mRNAs of survival genes and can promote pro-apoptotic gene expression. Acts as tumor suppressor in BC; overexpression triggers apoptosis in some TNBC cells. PMID: 26833120

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
mRNA
Breast Cancer
RNA Name: ZC3H12A

Mechanism of Action: RNase MCPIP1; degrades mRNAs of survival genes and can promote pro-apoptotic gene expression.

Effect on Cancer: Acts as tumor suppressor in BC; overexpression triggers apoptosis in some TNBC cells.

PMID: 26833120
CCAR1
mRNA 		Coactivator that augments p53-dependent transcription and is required for chemo-induced apoptosis. Activation induces apoptosis in TNBC cells via p38/JNK signaling. PMID: 27687593

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
mRNA
Breast Cancer
RNA Name: CCAR1

Mechanism of Action: Coactivator that augments p53-dependent transcription and is required for chemo-induced apoptosis.

Effect on Cancer: Activation induces apoptosis in TNBC cells via p38/JNK signaling.

PMID: 27687593
TRIAP1
mRNA 		TP53-regulated inhibitor of apoptosis 1; inhibits apoptosome formation and caspase-9 activation. Upregulated in drug-resistant breast cancer cells, contributing to chemo resistance. PMID: 25998939

External Database Search

STRING-DB miRTarDB PDB Encori TargetScan SM2miR DLnc OncoLnc Enrichr

Detailed Information

Apoptosis
mRNA
Breast Cancer
RNA Name: TRIAP1

Mechanism of Action: TP53-regulated inhibitor of apoptosis 1; inhibits apoptosome formation and caspase-9 activation.

Effect on Cancer: Upregulated in drug-resistant breast cancer cells, contributing to chemo resistance.

PMID: 25998939